Year: 2022

THE BIG QUESTION. "Nevertheless, germline DNA appears to remain sufficiently pristine to maintain fairly stable phenotypes over many generations. How do species avoid accumulating damage when composed of individuals that do?" http://www.publish.csiro.au/?paper=RD14514 View in LinkedIn

SURVIVING ACCUMULATED DAMAGE BY SPECIES. "One broad answer seems to be reproductive redundancy followed by elimination of defects through the death of gametes, embryos, fetuses, neonates and postpubertal individuals, with the culling pressure increasing as potential parents age." http://www.publish.csiro.au/?paper=RD14514 View in LinkedIn

SPECIES DAMAGE SURVIVAL. "Another major force appears to be evolutionary pressure; individuals that best fit the environment out-reproduce those that fit less well." http://www.publish.csiro.au/?paper=RD14514 View in LinkedIn

PROGENY OF AGED GERMLINE. "What is impressive is that older and older parents continue to have offspring that are nearly as pristine as those of younger parents, even though their germline cells have continued to age. Although the offspring of old parents are not as fit, on average, as those of young parents, differences are small and, in some species, compensated for by superior parenting with accumulated experience." http://www.publish.csiro.au/?paper=RD14514 View in LinkedIn

QUANDARY. "It appears that species do not age, even though they are composed of individuals whose somatic and germline cells have aged." http://www.publish.csiro.au/?paper=RD14514 View in LinkedIn

HUMANS have devised every snake-oil, potion, cream, elixir, serum, pills and similar nonsenses to try and stop the effects of aging, probably from time immemorial. These have given the topic of aging a bad reputation. But the reality is that if you examine nature, there are surprising examples that lead one to believe that aging as humans know it is neither hard-wired nor inevitable in living beings, that is, for some, at least. View in LinkedIn

STREAM OF ANTI-AGING MOVEMENTS. "In 1976, futurists Joel Kurtzman and Philip Gordon wrote No More Dying. The Conquest Of Aging And The Extension Of Human Life. In 1980, Saul Kent published The Life Extension Revolution. In 1983, Roy Walford, a life-extensionist and gerontologist, published a popular book called Maximum Lifespan. In 2003, The Immortal Cell: One Scientist's Quest to Solve the Mystery of Human Aging, by Michael D. West was published." https://lnkd.in/dSjbPFq View in LinkedIn

GOOGLE ANTI-AGING MOONSHOT. In 2013, Google announced Calico, a new company based in San Francisco that will focus on aging through new technologies, lead by the truly remarkable Arthur D. Levinson. "Announcing this new investment, Larry Page, Google CEO said: “Illness and aging affect all our families. With some longer term, moonshot thinking around healthcare and biotechnology, I believe we can improve millions of lives.” http://googlepress.blogspot.com.es/2013/09/calico-announcement.html?m=1 View in LinkedIn

HUMAN LONGEVITY INC. "J. Craig Venter's Human Longevity, Inc. has refueled in the race to build an industry-leading repository of genomes and associated data. The refueling took the form of a $220 million Series B round, which reportedly valued the company at upward of $1.2 billion and attracted the support of long-time HLI backers Celgene ($CELG) and Illumina ($ILMN)." https://lnkd.in/daDP7Qf View in LinkedIn

AGING IS NOT THERMODYNAMICALLY MANDATED. "Entropy (disorder) must increase inevitably within a closed system, but living beings are not closed systems. It is a defining feature of life that it takes in free energy from the environment and unloads its entropy as waste. Living systems can even build themselves up from seed, and routinely repair themselves. There is no thermodynamic necessity for senescence." https://lnkd.in/d9VA6CJ View in LinkedIn