linkedin post 2016-05-04 05:55:45

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LONG DISTANCE SIGNALS. "Cross-kingdom RNAi events demonstrate that gene silencing signals can travel extracellularly over long distances and, in terms of plant–microbe interaction, across plant and pathogen cell walls, membranes, cuticular layers and other cellular boundaries. However, the underlying mechanisms of trafficking of RNAi signals still remain enigmatic." https://lnkd.in/evpzgrd View in LinkedIn
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linkedin post 2016-05-04 06:01:57

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CONTRADICTORY RESULTS. "The presence of exogenous plant miRNAs and their kinetics in human and animal plasma/serum have been rigorously studied by various investigators ever since this discovery. Although some follow-up studies have detected plant miRNAs in human plasma, others have obtained contradictory results." https://lnkd.in/ejyM8yt View in LinkedIn
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linkedin post 2016-05-04 06:04:09

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DIFFERENCES. "A different group of researchers could not detect plant microRNAs after feeding in mice and studies in humans did not lead to detectable amounts of microRNAs in the plasma after consumption of fruits and broccoli sprouts. In contrast, Lukasik and Zielenkiewicz identified plant-derived microRNAs in exosomes of human and porcine breast milk and, by using a bioinformatics approach, predicted their potential human target mRNAs." https://lnkd.in/erkHGt5 View in LinkedIn
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linkedin post 2016-05-04 06:12:31

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CONDITION SPECIFIC. "The detected presence of plant miRNAs appears to depend on the type of diet fed to experimental animals, with clearly increased plasma levels being found a few hours after a meal. Some of these miRNAs were reported to affect gene expression in mammalian tissues." https://lnkd.in/e7k83PD View in LinkedIn
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linkedin post 2016-05-05 05:10:25

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STABLE MiRNAs. "It has been demonstrated by high-throughput sequencing that certain miRNAs from plants such as Zea mays (Z. mays), Arabidopsis thaliana (A. thaliana), Oryza sativa (O. sativa), and Citrus trifoliate (C. trifoliate) can exist stably in human plasma and breast milk exosomes, including 35 miRNAs from 25 MIR families." https://lnkd.in/eqwgs-g View in LinkedIn
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linkedin post 2016-05-05 05:12:10

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BREAST MILK. "A high number of microRNAs in human breast milk are present in microvesicles or exosomes which protect them from rapid degradation by RNases. It has been proposed that microRNAs are involved in cell–cell communication and play an important role in the immune system maturation of the infant." https://lnkd.in/erkHGt5 View in LinkedIn
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