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GRADUAL INTEGRATION. "The integration of new genes into GGI networks is a gradual evolutionary process. The new genes started, at a young age, to be integrated into networks to form new and less connected branches; however, with the elapse of evolutionary time, as genes grow older, they acquired more interacting links." (GGI = Gene-gene interaction networks)." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0772-4 View in LinkedIn

DEATH OF DE NOVO GENES. "The high rate of de novo gene birth in combination with a rather constant number of genes over time predicts that many of the de novo genes have only a short lifetime." http://www.sciencedirect.com/science/article/pii/S0168952515000347 View in LinkedIn

TRIUMPH OF DUPLICATION. "Speciation by genome duplication was recognized early in the study of evolutionary genetics and “represented the first major triumph in the genetics of speciation”. http://scholar.google.com/ View in LinkedIn

TWO KEY SEQUENCES. "Transcriptional regulatory sequences are as important for gene function as the coding sequences that determine the linear array of amino acids in a protein." https://lnkd.in/dTi6Znf View in LinkedIn

DYNAMIC PROCESS. "While gene family evolution is pervasive, it may be especially important in our own evolution since it appears that the "revolving door" of gene duplication and loss has undergone multiple accelerations in the lineage leading to humans." http://www.ncbi.nlm.nih.gov/pubmed/19153999 View in LinkedIn

MULTILEVEL CONTEXTUAL CONTROL. "Every gene with a phenotypic impact is flanked by regulatory sequences that, in conjunction with the expression and activity of proteins encoded elsewhere, regulate when expression occurs, at what level, under what environmental conditions, and in which cells or tissues." https://lnkd.in/dTi6Znf View in LinkedIn

DRIVERS OF TURNOVER. "One of the unique insights provided by the growing number of fully sequenced genomes is the pervasiveness of gene duplication and gene loss." https://lnkd.in/dMJvzp7 View in LinkedIn

COORDINATION IS CRITICAL. "A gene embedded in random DNA is inert. In the absence of sequence motifs and proteins capable of directing transcription, the protein it encodes will remain invisible to selection." https://lnkd.in/dTi6Znf View in LinkedIn

GENE TURNOVER. "The birth and death of genes is central to adaptive evolution, yet the underlying genome dynamics remain elusive." https://lnkd.in/d-Wf9Jd View in LinkedIn

NON-CODING TRANSCRIPTION. "Emerging evidence suggests that genomes transcribe a much larger repertoire of non-coding compared to protein-coding RNAs, a phenomenon that is more elaborate in complex organisms. Additionally, the number and types of known functional non-coding RNAs, short or long in size, has been significantly expanded, as these may be involved in cis or trans regulation of genes located in their vicinity or at distant loci." https://lnkd.in/ef6MAfH View in LinkedIn