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MAJOR PLAYERS. “These results are compatible with the view that TEs are major contributors to the origin and evolution of lincRNAs.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

UNCHARACTERIZED. “The current knowledge on the functions of long intergenic non-coding RNAs (lincRNAs) is scarce because very few of the lincRNAs have been experimentally characterized.” https://lnkd.in/dwuaM5f View in LinkedIn

EXON AND PROMOTOR CONCENTRATION. “The content of TES in lincRNA genes is substantially greater than in protein-coding genes, particularly in exons and promoter regions.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

INTRON CONCENTRATION. “We found that introns of lincRNA genes contain the highest fraction of TES, followed by exons. The promoters of the lincRNAs contain the lowest fraction of TES but the largest fraction of ancient TES that are conserved between primates and rodents.” (TES = Transposable element-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

VIRAL CONTRIBUTION. “The TES are likely to have substantially contributed to evolutionary change in both gene specific and global patterns of mammalian protein-coding gene regulation.” (TES = Transposable element-derived sequences). https://lnkd.in/dwuaM5f View in LinkedIn

VIRAL-DERIVED REGULATORS. “Thus, thousands of human (and other mammalian) genes appear to be regulated, at least in part, by sequences derived from TEs.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

VIRAL RELICS IN MAN. “Different classes of regulatory regions in the human genome have been surveyed for the presence of TE-derived sequences (TES) to systematically assess the potential contribution of TEs to the regulation of human genes, and almost 25% of the analyzed promoter regions have been found to contain TES.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

VIRAL CONTRIBUTION. “The TEs are the primary contributors to the bulk of the genomic DNA in many eukaryotes, in particular mammals, and have the potential to contribute to the evolution of the hosts by providing novel regulatory or coding sequences.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

FAMILY OF FOSSILS. “Retrotransposons including long interspersed repetitive elements (LINEs), short interspersed repetitive elements (SINEs), and long terminal repeat (LTR) retrotransposons are widely represented in mammals.” https://lnkd.in/dwuaM5f View in LinkedIn

ABUNDANT VIRAL FOSSILS. “Diverse TEs are widespread and abundant in the genomes of most eukaryotes. Different classes of TEs include mobile retrovirus-like elements, or retrotransposons, which transpose within the genome via RNA intermediates, and DNA transposons, which can relocate directly.” (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn