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VARIED EXPRESSION. "Posttranscriptional mechanisms notwithstanding, the available body of work suggests that variation in steady-state gene expression levels can disproportionately be explained by variation in TF binding." (TF = transcription factor). https://lnkd.in/dFv6Tsi View in LinkedIn

TRANS-VARIANTS. "Heritability studies suggest that more than half of the genetically explained variance in gene expression is due to trans-acting variants." https://lnkd.in/dFv6Tsi View in LinkedIn

INTRONS AND MICRO-RNA. "Introns as catalysts for de novo miRNA family origination in mammals. A detailed analysis revealed that 36%–65% of miRNA genes are overlapping with introns of protein-coding genes in the different species, although annotated introns only constitute ∼22%–45% of the entire genome. Introns may represent a natural place for the miRNA de novo formation." https://lnkd.in/dDg9xVY View in LinkedIn

PATHOGEN VIRILITY DRIVER. "The intensity of local competition for susceptible hosts depends, however, on the precise genetic and epidemiological structure of the pathogen population." https://lnkd.in/dvcWSUt View in LinkedIn

THIRD GENOMIC EVOLUTION DRIVERS "are other non-coding regions of the genome that make up the so-called cis-regulatory network, which controls the production of mRNA and thereby of proteins according to factors such as cell type or environmental conditions." https://lnkd.in/eNHFjJ8 View in LinkedIn

PROXIMITY. "Localized transmission often favours more prudent host exploitation strategies. Indeed, when epidemics are spatially structured, extreme strategies of host exploitation may lead to the over-exploitation of the local host supply and therefore fail to invade." https://lnkd.in/dvcWSUt View in LinkedIn

SECOND GENOMIC EVOLUTION DRIVERS "are miRNAs, which regulate the activity of messenger RNAs (mRNA) after transcription." https://lnkd.in/eNHFjJ8 View in LinkedIn

LIFE CYCLE OF INFECTION. "We recently tested this idea using the bacteriophage λ in experimental epidemics spreading through well-mixed environments. We confirmed that more virulent strains are indeed selected for during early epidemics, when uninfected hosts are abundant, but also that natural selection favours latent strains of the virus as disease prevalence increases." https://lnkd.in/dvcWSUt View in LinkedIn

FIRST GENOMIC EVOLUTION DRIVER. "Three crucial drivers of genomic evolution. The first drivers are protein-encoding genes themselves—which Berjerano described as the ‘big beasts' of evolution—around which the rest of the genome revolves." https://lnkd.in/eNHFjJ8 View in LinkedIn

NATURAL BRAKES. "Decreased availability of susceptible hosts weakens selection for higher transmission rates. Ultimately, this may select for intermediate evolutionarily stable strategies, balancing the benefit (transmission) and the cost (virulence: induced host mortality) of host exploitation." https://lnkd.in/dvcWSUt View in LinkedIn