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TERM CHIMAERAS. "Previous attempts to achieve development to term of aggregation chimaeras between parthenogenetic and fertilised embryos were apparently unsuccessful. We have introduced inner cell masses (ICMs) from diploid, parthenogenetic embryos into intact fertilised mouse blastocysts, and we report here the development of a chimaera to term." https://lnkd.in/gAXZaG6 View in LinkedIn

BIMATERNAL MAMMALS. "Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. We thus establish a novel strategy of generating bimaternal mammals, which is valuable to uncover the function of genomic imprinting, and to improve assisted reproduction in diverse mammalian species." https://lnkd.in/gCT7Dcz View in LinkedIn

CHIMAERAS. "Teratocarcinoma cells and cells carrying known lethal alleles can develop into viable chimaeras when aggregated with cells from normal embryos." http://www.nature.com/nature/journal/v270/n5638/abs/270601a0.html View in LinkedIn

TWO GAMETES NEEDED. "Normal mammalian development requires participation of both maternal and paternal genomes because of the existence of genomic imprinting, whereas the gynogenetic and androgenetic embryos die shortly after implantation." https://lnkd.in/gCT7Dcz View in LinkedIn

DIPLOID PARTHENOGENESIS. "Development to term of chimaeras between diploid parthenogenetic and fertilised embryos. Parthenogenic mouse embryos have the potential for extensive cellular proliferation as well as differentiation into various cell types. But this potential has been realised only when parthenogenetic embryos have been transferred to extrauterine sites, and in spontaneously occurring ovarian teratomas and teratocarcinomas of parthenogenetic origin." https://lnkd.in/gAXZaG6 View in LinkedIn

ALTERNATIVE GAMETES. "Recently, we and others have derived mammalian androgenetic and parthenogenetic haploid embryonic stem cells (ahESCs and phESCs), and showed that ahESCs can replace gametes to produce offspring, which provided alternative resources for reproduction." https://lnkd.in/gCT7Dcz View in LinkedIn

PURE LINE HAPLOID PLANTS. "Lettuce (Lactuca sativa L.), a well-known and popular leafy vegetable, is consumed worldwide. Its haploid form would provide a good basis for producing a pure line of plants (doubled haploids) allowing new varieties to be regenerated." https://lnkd.in/g4mkgn7 View in LinkedIn

ARTIFICIAL HAPLOIDS. "For the artificial production of haploids several methods are known to be useful, such as crosses between distantly related species, pollination with X-rayed pollen, selection of twin seedlings and delayed pollination. However, the tendency to haploid parthenogenesis is controlled by the genetic make-up of a given strain and an application of those methods may be not always successful." https://lnkd.in/gZ6EwgN View in LinkedIn

PLANT ENGINEERING. "Haploidisation is a biotechnological method used to obtain plants with improved traits that are of use to humans." https://lnkd.in/g4mkgn7 View in LinkedIn

CROP HAPLOIDS. "Haploid plants (characterized by gametic number of chromosomes) are both significant and necessary elements in plant improvement programs. They are important in many basic research disciplines, such as biotechnology, genetics, crop evolution and plant breeding. Moreover, haploids are very useful as a base for the production of homozygous plants in that they expedite the breeding process and can lead to an increase in crop yield." https://lnkd.in/g4mkgn7 View in LinkedIn