Category: Uncategorized

LINEAR PLUSES. "In the reductional division of meiosis, the homologous chromosomes are held together by their chiasmata where recombination has generated a crossover between homologous chromatids. A single meiotic crossover (or any uneven number of crossovers) generates a dicentric circle, which will lead to non-disjunction of the homologs. As this problem is circumvented with linear chromosomes, linearization may have provided a selective advantage." https://lnkd.in/d8Qr_bk View in LinkedIn

POTENT DRIVERS. "New genes now appear to be potent drivers of phenotypic evolution and the genetic control of important biological processes, and show that organismal development and organ development have evolved species-specific and lineage-specific components." https://lnkd.in/dvpUaYF View in LinkedIn

PLOIDY SWITCHES. "It was argued that switching between diploid and haploid states poses a problem for organisms with circular chromosomes." https://lnkd.in/d8Qr_bk View in LinkedIn

BECOMING ESSENTIAL. "Surprisingly, new genes can quickly acquire essential roles in development. Chen et al., identified 59 genes that originated in the last ~35 MYs in Drosophila that evolved essential developmental functions. Silencing new genes can also have a critical effect on reproduction, even when the individual can complete development." https://lnkd.in/dvpUaYF View in LinkedIn

SYNGAMIC FUSION. "The counterpart of meiosis, the syngamic fusion of haploid cells to form diploids may have been advantageous to survive famine as well as providing greater resistance to the highly mutagenic environment that existed 1 Gy ago." https://lnkd.in/d8Qr_bk View in LinkedIn

TELOMERE COMPLEXITY. "The scenario sketched above raised the question why telomeres became so elaborate. Why not stick with the simple t-loop mode? Why have telomerase and a host of telomeric proteins?" https://lnkd.in/d8Qr_bk View in LinkedIn

STABILIZATION PHASE. "After a period of semi-stable linear chromosomes, a more permanent linear state would have required the gradual evolution toward the system used by modern telomeres." https://lnkd.in/d8Qr_bk View in LinkedIn

FLIP-FLOPPERS. "The earliest eukaryotic chromosomes may have existed predominantly as linears that occasionally were converted to a circular state." https://lnkd.in/d8Qr_bk View in LinkedIn

INTRON CONSEQUENCES. "I propose that accumulation of Group II introns in the genome could also have generated the condition under which linear chromosomes became inevitable." https://lnkd.in/d8Qr_bk View in LinkedIn

NECESSITY FOR NUCLEUS. "The invasion of Group II introns may have also led to nonsense-mediated decay as a way to remove intron-bearing transcripts from ribosomes but generation of a nuclear envelope combined with a system that links mRNA transport to the completion of splicing is a more definitive solution." https://lnkd.in/d8Qr_bk View in LinkedIn