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STABILIZATION PHASE. "After a period of semi-stable linear chromosomes, a more permanent linear state would have required the gradual evolution toward the system used by modern telomeres." https://lnkd.in/d8Qr_bk View in LinkedIn

FLIP-FLOPPERS. "The earliest eukaryotic chromosomes may have existed predominantly as linears that occasionally were converted to a circular state." https://lnkd.in/d8Qr_bk View in LinkedIn

INTRON CONSEQUENCES. "I propose that accumulation of Group II introns in the genome could also have generated the condition under which linear chromosomes became inevitable." https://lnkd.in/d8Qr_bk View in LinkedIn

NECESSITY FOR NUCLEUS. "The invasion of Group II introns may have also led to nonsense-mediated decay as a way to remove intron-bearing transcripts from ribosomes but generation of a nuclear envelope combined with a system that links mRNA transport to the completion of splicing is a more definitive solution." https://lnkd.in/d8Qr_bk View in LinkedIn

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RISE OF POLYPLOIDY. "The evolution of meiosis resulted in homolog chromosome pairing, independent assortment, chiasmata-based crossing over, and ploidy changes (2N to 4N to 2N to 1N)." http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn

PLAGUE REMOVAL. "The insertion of Group II introns into coding regions could have provided the selective pressure for the invention of the nucleus as a compartment where introns can be removed from pre-mRNAs before they are used by ribosome." https://lnkd.in/d8Qr_bk View in LinkedIn

WHY LINEAR #2. "Even crossing over between one linear and one circular chromosome will yield a linear dicentric that would also be unstable. The advent of sexual crosses may well have driven the advent of the linear chromosome: An ancestral protoeukaryote might have had two circular chromosomes with centromeres; their recombination would have yielded a circular dicentric that, when subjected to incomplete breakage-fusion-reunion cycles, could have given rise to linear chromosomes." https://lnkd.in/ebVhXPf View in LinkedIn

REPETITIVE ELEMENT PLAGUE. "The Group II introns residing in the genome of the ingested future mitochondrion are proposed to have colonized the host genome resulting in a large number of repetitive elements." https://lnkd.in/d8Qr_bk View in LinkedIn