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ANCESTRAL RETROTRANSPOSONS. "I propose that mobile Group II self-splicing elements (Group II introns) are a good candidate for the repeats that led to chromosome linearization. Group II introns are the proposed ancestors of introns and non-LTR retrotransposons." https://lnkd.in/d8Qr_bk View in LinkedIn

INFREQUENT EXAMPLES. "As logical as genomic streamlining might be, few examples have so far been found. Instead, a bevy of articles from the last 10 years show that three separate lines of evidence argue against widespread streamlining in prokaryotes." https://lnkd.in/d3Ys7Am View in LinkedIn

GENOMIC STREAMLINING. "Genomic researchers have proposed that natural selection may favor small genomes—weeding out superfluous material—through a process called “genomic streamlining.” Streamlining makes inherent sense because a small genome should aid metabolic efficiency, because genome size is correlated with cell size." https://lnkd.in/d3Ys7Am View in LinkedIn

GENOME DOWNSIZING. "Evolutionary chromosome change involves significant variation in DNA amount in diploids and genome downsizing in polyploids." https://lnkd.in/dmkwGfy View in LinkedIn

SIMPLICITY NOT SELECTED. "In part, the answer must be that most processes in eukaryotes generally evolve toward complexity, presumably because complexity provides more regulatory opportunities and perhaps also because there is no selective pressure to enforce simplicity." Not always true. https://lnkd.in/d8Qr_bk View in LinkedIn

SPLICEOSOME COMPLEXITY. "The same question could be asked about intron splicing which evolved from simple self-splicing based on RNA catalysis to elaborate spliceosomal complexes with a myriad of RNA and protein components." https://lnkd.in/d8Qr_bk View in LinkedIn

TELOMERE COMPLEXITY. "The scenario sketched above raised the question why telomeres became so elaborate. Why not stick with the simple t-loop mode? Why have telomerase and a host of telomeric proteins?" https://lnkd.in/d8Qr_bk View in LinkedIn

STABILIZATION PHASE. "After a period of semi-stable linear chromosomes, a more permanent linear state would have required the gradual evolution toward the system used by modern telomeres." https://lnkd.in/d8Qr_bk View in LinkedIn

FLIP-FLOPPERS. "The earliest eukaryotic chromosomes may have existed predominantly as linears that occasionally were converted to a circular state." https://lnkd.in/d8Qr_bk View in LinkedIn

INTRON CONSEQUENCES. "I propose that accumulation of Group II introns in the genome could also have generated the condition under which linear chromosomes became inevitable." https://lnkd.in/d8Qr_bk View in LinkedIn