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MOLECULAR SELECTION. "Purifying selection, the purging of deleterious variants from the population, is the most common mode of operation of selection. At the molecular level, purifying selection is commonly seen in the maintenance of sequence motifs whose degradation decreases the fitness of the organism." https://lnkd.in/drMDPh6 View in LinkedIn

REGULATORY FUNCTIONS. "Bearing in mind that the vast majority of the mammalian genome is dynamically transcribed in different cells and developmental stages, these observations are consistent with the hypothesis that non coding RNAs are prevalent molecular conveyors of regulatory plasticity in mammals." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

FUNCTIONAL DARK MATTER. "Our findings reappraise the amount of functional sequence in mammalian genomes through comparative genomics by providing further evidence for widespread negative selection at the transcriptomic level." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

MILLIONS OF CANDIDATES. "Although this work identifies millions of putative functional RNA structures, their exact functional nature remains largely uncharted. One way to achieve this is by clustering them into families based on their structural topologies, thus deriving function via homology—an approach that has been applied to smaller sets of RNA structures." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

OLD PARADIGM REFUTED. "Our findings provide an additional layer of support for previous reports advancing that >20% of the human genome is subjected to evolutionary selection, while suggesting that additional evidence for function can be uncovered through careful investigation of analytically involute higher-order RNA structures." http://nar.oxfordjournals.org/content/early/2013/07/11/nar.gkt596.full View in LinkedIn

TWO KINGDOM MYOPIA: PLANTS VS ANIMALS. The new five kingdom system of classification overcomes some previous problems. https://lnkd.in/gYETt8v View in LinkedIn

FRAGMENT FROM NATURE contemplates swarm behavior, swarm intelligence and individuality versus community living in the humble slime mold. You may find a slime mold in your back garden or in the local woods. But these creatures are far from simple. Without a brain, or with a nervous system, they are capable of remarkably complex data processing: thinking without a nervous system. View in LinkedIn

QUESTION 2. "Why Would Genes that Have a Higher Density of Introns be More Enriched in exonic splice enhancers?" https://lnkd.in/drMDPh6 View in LinkedIn

CHEMICALS AND PULSES. “Cells in close spatial proximity to one another eventually synchronise, resulting in multiple ‘competing’ pulse centres. As some oscillatory centres accumulate more cells by chance, cAMP concentrations in the surrounding areas increase, causing oscillatory centres to pulse at a faster rate, thereby releasing more cAMP into the environment.” https://academic.oup.com/femsre/article/40/6/798/2400841 View in LinkedIn

QUESTION 1. "What Could be the Function(s) of exonic splice enhancers in Intronless Genes?" https://lnkd.in/drMDPh6 View in LinkedIn