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FUTILE SEARCH. "The failure of grafted normal cells to replicate indefinitely in vivo means that, given the "perfect" conditions of nutrition and environment that an isologous animal represents, transplanted normal cells are still incapable of immortality. This leads to the further conclusion that a search for perfect in vitro conditions in which normal cells might reveal immortality is futile." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

THE MORTALITY REALITY. "As Weismann opined, renewal cell populations do not occur in most tissues, and when the do, cell proliferation is not indefinite. In vitro experiments yield similar results. Serially cultured normal cells are mortal and reveal age changes before they die." (Normal cells). http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

THE IMMORTALITY CONDITION. "If all cell types were continually renewed without loss of function or capacity for self-renewal, organs composed of such cells would be expected to function normally indefinitely. Their host would live forever." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

CRYOGENIC PRESERVATION. "The cells have an extraordinary memory and "remember" at what doubling level the were preserved even after 35 years of continuous storage in liquid nitrogen. WI-38 has been cryogenically preserved longer than any other normal human or animal cell population." (There is a very interesting story behind WI-38 cells if you care to look it up). http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

FRAGMENT FROM NATURE deals with the quirky orchid family. Few plant families are as diverse as orchids, and with diversity comes a dazzling array of strategies for getting ahead. They illustrate how one plant family can be so creative in employing different complicated structures and behaviors especially in reproduction. Enjoy this glorious group. View in LinkedIn

PROPERTIES OF MORTAL CELLS #5. "Human diploid cell strains can be cryogenically preserved. When, for example, our first widely distributed normal human diploid cell strain WI-38, developed in 1962, is preserved at a particular doubling level and then reconstituted, the number of doublings remaining is equivalent to 50 minus the number of doublings spent prior to preservation." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

NAIL IN COFFIN TO HYPOTHESIS. "Cells aging in vitro do, indeed, acquire hundreds of incremental and decremental physiological changes as the approach the end of their in vitro lifespan. Yet, none of these changes raise the cell to a higher level of differentiation or specialization. To call the Phase III Phenomenon differentiation seems entirely inappropriate." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

PROPERTIES OF MORTAL CELLS #4. "Human cell strains will not produce tumors when inoculated into the hamster cheek pouch or even when directly inoculated into terminal human cancer patients." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

TERMINAL DIFFERENTIATION HYPOTHESIS. "Presently, the only alternative explanation of the limited proliferative capacity of normal cells that competes with the notion that it represents aging at the cellular level is the conjecture that it might represent terminal differentiation." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

PROPERTIES OF MORTAL CELLS #3. "If derived from normal tissue, cell strains have the diploid karyotype and unlike immortal cell lines, normal cell strains are incapable of replication in suspension culture. This property is now called anchorage dependence." http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn