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OUTSOURCED FUNCTIONS. "It is also evident that certain functions vital for protecting transgenerational genome integrity in animal germ cells, such as the suppression of transposition in the germ cell genome, has been partially “outsourced” to gametophytic helper cells in plants." (Targeted at suppressing parasitic mobile genetic elements by transposing silencing). http://www.sciencedirect.com/science/article/pii/S1534580713000427 View in LinkedIn

HUMAN ALU REPEAT. “Over 5% of the mammalian genome consists of short interspersed elements (SINEs), typified by the human Alu repeat. These are RNA polymerase III transcribed sequences whose expression is usually silenced. However, upon prolonged exposure to DNA damaging agents that predominantly cause double strand breaks, transcription from the human Alu elements and murine SINEs is strongly induced.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn

DNA DAMAGE RESPONSE. “Several different types of non-coding RNAs have been implicated in the DNA damage response. For example, many microRNAs (miRNAs) regulate genes that are involved in the DNA damage response." http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn

IMPORTANT REVIEW. “Here we will discuss how non-coding RNAs contribute to the relationships among chromatin structure, genomic integrity, and cellular senescence." http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn

CHROMATIN. “Given the critical role of chromatin in regulating genomic stability and gene expression, it is tempting to speculate that some of the changes in gene expression and genomic integrity that occur during aging may be caused by the global changes to the chromatin structure that accompany aging.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn

DAMAGE CONTROL. “Genomic stability is closely intertwined with the chromatin structure. The chromatin structure not only regulates the accessibility of DNA damaging agents to the genome, but also plays critical roles in the signaling of DNA lesions and their repair.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn

DAMAGE. “The accumulation of DNA damage is a hallmark of aging and senescing cells, and the DNA damage signal emanating from shortened telomeres triggers cells to enter a state of senescence.” https://lnkd.in/dKvxxVz View in LinkedIn

LIFESPAN AND GENOMES. “Although numerous different pathways for aging have been proposed, it is striking that human premature aging syndromes are caused by defects in the maintenance of genomic stability, indicating that genomic integrity plays a key role in determining lifespan.” https://lnkd.in/dKvxxVz View in LinkedIn

EARLY PREDICTION. “The notion that repetitive copies of functional genes might govern, or trigger, the aging process had been suggested earlier by Medvedev. It was not until recently, however, that Olovnikov's remarkably insightful speculation was proven to be correct experimentally.” http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

REPEATS AND SENESCENCE. “Induction of non-coding RNA transcription from the repetitive Alu elements occurs during human stem cell aging and hinders efficient DNA repair causing entry into senescence.” http://journal.frontiersin.org/article/10.3389/fgene.2013.00136/full View in LinkedIn