linkedin post 2019-04-07 04:35:18

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METABOLIC INNOVATION. "Escape from Muller’s ratchet can be considered the most fundamental benefit of HGT in microbial evolution but it certainly is not the only one. Acquisition of new genes and whole operons appears to be the principal route of metabolic network expansion in microbes." (HGT = horizontal gene transfer). https://lnkd.in/dSemZpD View in LinkedIn
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linkedin post 2019-04-07 04:32:49

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PROTECTION. "The model shows that, thanks to the stochastic nature of the mutation process, protection from the ratchet is achievable despite the fact that environmental DNA that comes from dead microbes on average has a higher mutational load than the DNA of living recipient cells." https://lnkd.in/dSemZpD View in LinkedIn
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linkedin post 2019-04-07 04:30:10

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OFFSETTING THE RATCHET. "The only route of actual escape from Muller’s ratchet appears to be gene acquisition via HGT resulting in either displacement of a mutated gene by a functional copy or gain of new genes that offsets the deleterious effects of accumulating mutations." (HGT = horizontal gene transfer). https://lnkd.in/dSemZpD View in LinkedIn
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linkedin post 2019-04-07 04:27:55

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ASEXUAL DEAD END. "Clonal populations typically deteriorate due to the action of the evolutionary mechanism known as Muller’s ratchet, i.e. gradual loss of fitness and eventual extinction caused by accumulation of slightly deleterious mutations via genetic drift." https://lnkd.in/dSemZpD View in LinkedIn
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linkedin post 2019-04-07 04:26:52

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DEPENDENT ON HGT. "Can microbes evolve without substantial HGT, simply via the competition of clonal populations? Apparently not, as population genetic modeling indicates that this evolutionary regime is unsustainable in the long term." (HGT = horizontal gene transfer). https://lnkd.in/dSemZpD View in LinkedIn
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