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PROMISCUOUS BINDING. "Of particular interest in the context of protein-protein interaction networks are findings demonstrating that proteins with many or large intrinsically disordered segments often have the ability to bind promiscuously, with promiscuous proteins or protein segments being those that can bind to many different targets." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

DECEITFUL BEHAVIOR. “After 500 generations, 60 percent of the robots had evolved to keep their light off when they found the good resource, hogging it all for themselves. Even more telling, a third of the robots evolved to actually look for the liars by developing an aversion to the light; the exact opposite of their original programming!" http://www.popsci.com/scitech/article/2009-08/evolving-robots-learn-lie-hide-resources-each-other View in LinkedIn

THREE MODULES. "There appear to be three different modules within intrinsically disordered regions responsible for their functionally promiscuous behaviour: MoRFs (molecular recognition features), SLiMs (small linear motifs) and LCRs (low complexity regions)." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

DESIGN FOR LYING TEST. "The experiment involved 1,000 robots divided into 10 different groups. Each robot had a sensor, a blue light, and its own 264-bit binary code "genome" that governed how it reacted to different stimuli. The first generation robots were programmed to turn the light on when they found the good resource, helping the other robots in the group find it." https://lnkd.in/g_45Y2T View in LinkedIn

CONFORMATIONALLY LOOSE. "Intrinsically disordered segments lack a unique three-dimensional structure, either entirely or in parts, when expressed as autonomous units, and it is assumed that they sample a variety of conformations that are in equilibrium under physiological conditions." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

EVOLVING ROBOTS LEARN TO LIE. "In an experiment run at the Laboratory of Intelligent Systems in the Ecole Polytechnique Fédérale of Lausanne, Switzerland, robots that were designed to cooperate in searching out a beneficial resource and avoiding a poisonous one learned to lie to each other in an attempt to hoard the resource." https://lnkd.in/g_45Y2T View in LinkedIn

ABUNDANT DISORDER. "That it is essential to understand the interaction patterns of proteins with large intrinsically disordered segments becomes evident in the light of their abundance in higher eukaryotes (about 30–40% of their proteins contain large disordered segments) and the finding that proteins enriched in disorder are crucial for cellular processes such as transcription and signal transduction." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

PERPETUAL EMERGENCE. "Substantial effort in the genetic programming community is dedicated to exploring avenues for designing solutions to hard problems. In an ideal situation the solution would adapt to unseen new problems in a satisfactory manner. In our view, this can be achieved to a great extent if mechanisms for allowing perpetual emergence and autonomous response to emerging properties, not requiring external intervention, are put in place." http://eprints.aston.ac.uk/20778/1/Emergence_in_genetic_programming.pdf View in LinkedIn

SYNERGY CREATES PLASTICITY. "The notion that disordered regions are largely passive is being actively challenged by the idea that they perform diverse functions, and that synergy between structured and disordered regions expands the functional repertoires of proteins." http://science.sciencemag.org/content/337/6101/1460 View in LinkedIn

TWO ORDERS. "Many protein functions can be attributed to segments (domains) that fold independently and adopt specific three-dimensional structures. Intrinsically disordered regions are unstructured segments whose amino acid compositions prevent autonomous folding. Some eukaryotic proteins are either fully disordered (intrinsically disordered proteins) or structured, but most have both types of regions." https://lnkd.in/dKEH6Bf View in LinkedIn