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CONTRARIAN. “We will not assume...that AI progress will accelerate rather than decelerate.” https://lnkd.in/dAZH9Vg View in LinkedIn

ASSUMPTIONS. “We will not assume the continuation of Moore’s law, nor that hardware trajectories determine software progress, nor that faster computer speeds necessarily imply faster “thought”, nor that technological trends will be exponential.” https://lnkd.in/dAZH9Vg View in LinkedIn

WILLFUL MUTANTS. “The ability genetically to hack one's own source code will unleash an exponential growth of genomic rewrites - not mere genetic tinkering but a comprehensive redesign of "human nature".” http://www.biointelligence-explosion.com/ View in LinkedIn

REPLICATION. “Viruses are genetic material encased in protein. They self-replicate and cause disease. Prions are just proteins. They self-replicate and cause disease. How viruses and prions work. Self-replication by hijacking or inducing mis-folding, respectively, might not be what biologists have in mind for self-replication, but the end result is still more virus particles and prions in the world.” https://lnkd.in/dzZgRcM View in LinkedIn

FUTURIST VISION. "As the era of open-source genetics unfolds, tomorrow's biohackers will add, delete, edit and customise their own legacy code in a positive feedback loop of cognitive enhancement.” http://www.biointelligence-explosion.com/ View in LinkedIn

PRIONS “can multiply exponentially and can pass through membranes; transmission can occur between individual (e.g. by blood); they can even be transmitted between different species; they are resistant against proteases (enzymes that break down proteins) and the body’s defense mechanisms; they can mutate, creating different forms of pathogenic prions.” https://lnkd.in/dN2v7fv View in LinkedIn

THE CYCLE. “The accelerating growth of germline engineering will be a comparatively slow process. In this scenario, sentient biological machines will design cognitively self-amplifying biological machines who will design cognitively self-amplifying biological machines.” http://www.biointelligence-explosion.com/ View in LinkedIn

ORIGINS. “During the emergence of metazoa, a cysteine-flanked core domain was inserted, or de novo arose, in a pre-existing ZIP ancestor gene to generate a prion-like ectodomain in a sub-branch of ZIP genes. Approximately a half-billion years later, a genomic insertion of a spliced transcript coding for such a prion-like ZIP ectodomain may have created the prion founder gene.” https://lnkd.in/d9yFgCg View in LinkedIn

THE DELTA. “Genetic evolution is slow. Progress in artificial intelligence is fast. Only a handful of genes separate Homo sapiens from our hominid ancestors on the African savannah. Among our 23,000-odd protein-coding genes, variance in single nucleotide polymorphisms ("SNPs") accounts for just a small percentage of phenotypic variance in intelligence as measured by what we call IQ tests.” http://www.biointelligence-explosion.com/ View in LinkedIn

PRIONS ARE MADE BY GENES and the gene products, proteins, are transmissible pathogens. Prions amplify their variant conformation but need genes to be created in the first place. https://lnkd.in/dkdVKcb View in LinkedIn