linkedin post 2019-12-14 06:32:14
ALTERNATIVE mRNA SPLICING ANIMATION. https://lnkd.in/deH8aJG View in LinkedIn
linkedin post 2019-12-14 06:31:12
VARIABLE RNA MESSAGE. "Changes in cutting and pasting alter the meaning of the document, often quite dramatically. Similarly, alternative splicing of RNA leads to a variety of possible mRNA isoforms and proteins, which can have different, and often opposing, functions." http://www.nature.com/scitable/topicpage/regulation-of-mrna-splicing-by-signal-transduction-14128469 View in LinkedIn
linkedin post 2019-12-14 06:29:54
FIXED DNA MESSAGE (NEARLY). "Genomic DNA is like a word-processing document that is "read-only" with no changes possible, whereas the RNA is a transcript of the document that permits, and even requires, cutting and pasting to get to the final version." http://www.nature.com/scitable/topicpage/regulation-of-mrna-splicing-by-signal-transduction-14128469 View in LinkedIn
linkedin post 2019-12-15 05:31:55
SO ENDS this first of two weekends contemplating the genetic origin of protein diversity in organisms and its consequences. This mechanism is at the heart of generating protein diversity from a relatively small deck of genetic cards, and thus, is at the heart of the capacity to evolve and develop new functionality from different structures. By constantly varying the structures of core motifs, new protein functions can be found by trial and error. Whether there is any statistical bias will reveal whether life can be capable of directing its own evolution in a goal-oriented manner. View in LinkedIn
linkedin post 2019-12-15 05:23:59
ALTERNATIVE SPLICING "produces multiple mRNAs from the same gene through variable selection of splice sites during pre-mRNA splicing. It plays a key regulatory role in modulating gene expression during development and in response to environmental signals." http://www.sciencedirect.com/science/article/pii/S1360138512001276 View in LinkedIn
linkedin post 2019-12-15 05:23:03
EXON SKIPPING. "Alternative inclusion or exclusion of exons—“exon skipping”—can generate protein isoforms with distinct subcellular localization, enzymatic activity or allosteric regulation, and differing, even opposing, biological function." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn
linkedin post 2019-12-15 05:21:20
"THE SPLIT STRUCTURE of eukaryotic genes impacts gene expression and evolution in diverse ways. Most directly, the presence of introns enables multiple distinct mRNA and protein products to be produced from the same gene locus through alternative splicing, which is often regulated between tissues or developmental stages." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn
linkedin post 2019-12-15 05:19:34
CRUCIAL ROLES. "Most human genes are alternatively spliced, allowing the selection of different combinations of exons to produce multiple distinct mRNAs and proteins. Many types of alternative splicing are known to play crucial roles in biological processes including cell fate determination, tumor metabolism, and apoptosis." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn
linkedin post 2019-12-15 05:18:30
WHEAT AND CHAFF. "In order to translate a gene into protein, all of the non-coding regions (introns) need to be removed from the transcript and the coding regions (exons) stitched back together to make an mRNA." https://lnkd.in/dCxe2iF View in LinkedIn
linkedin post 2019-12-15 05:15:18
SPLICEOSOME. "Splicing is carried out by the spliceosome, a massive structure in which five small nuclear ribonucleoprotein particles (snRNPs) and a large number of auxiliary proteins cooperate to accurately recognize the splice sites and catalyse the two steps of the splicing reaction." https://lnkd.in/d5-PmqK View in LinkedIn