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ADDS TO COMPLEXITY. "Together with gene duplication and recombination, alternative splicing plays a major role in increasing proteome diversity and organismal complexity." http://www.sciencedirect.com/science/article/pii/S1097276512004844 View in LinkedIn

BIOHACKERS. “In 2014, Phil Kennedy hired a neurosurgeon in Belize to implant several electrodes in his brain and then insert a set of electronic components beneath his scalp. Back at home, Kennedy used this system to record his own brain signals in a months-long battery of experiments. His goal: Crack the neural code of human speech. Yes, it’s possible to communicate directly via your brain waves. But it’s excruciatingly slow. Other substitutes for speech get the job done faster.” http://www.wired.com/2016/01/phil-kennedy-mind-control-computer/ View in LinkedIn

DISTINCT. "Tissue-regulated alternative coding exons and flanking constitutive exons less often overlapped folded protein domains compared to general alternative exons." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

CONSERVED EXONS. "Interestingly, tissue-regulated exons associated with the highest rates of disordered amino acids also tended to be the most highly conserved. For example, 63% of the 101 most disordered human brain, skeletal, and or heart-differentially spliced exons are also alternatively spliced in mouse, whereas only 31% of the least disordered 81 exons differentially spliced in these tissues were detected as alternatively spliced exons." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

DISORDER AND INTERACTIONS. "We systematically investigate properties of tissue-regulated alternative exons. We find that proteins containing these coding exons tend to have more interactions in PPI networks. Moreover, these exons, together with the flanking constitutive exons, are enriched in sequences predicted to be highly disordered." (PPI = protein-protein interactions). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

ALTERNATIVE EXONS. "In contrast, differentially regulated alternative exons have not been examined for common functional features. This is an important issue to address, since these exons are generally conserved and maintain frame. Moreover, because they comprise only 10%–30% of total alternative exons, they may possess important functional features that have been overlooked." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

DISORDERED SEQUENCES. "Since disordered regions are highly enriched in ligand binding surfaces and posttranslational modification, this suggests that AS may frequently modulate protein-protein and other ligand interactions." (AS = alternative splicing). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn