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DISORDERED SEQUENCES. "Since disordered regions are highly enriched in ligand binding surfaces and posttranslational modification, this suggests that AS may frequently modulate protein-protein and other ligand interactions." (AS = alternative splicing). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

TERTIARY STRUCTURE. "Analysis of splicing and protein tertiary structure has suggested that alternative exons can have diverse effects on protein folding and function but are also found on the surfaces, within loops or in predicted disordered regions of proteins." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

EXON SUBSETS. "Specific subsets of alternative exons, or “exon networks,” display coordinated regulation between different cell types or conditions. Such exons are often evolutionarily conserved and enriched in genes with related functions, implying that they are involved in important processes or pathway-specific activities. To date, however, the functions of alternative exons within these networks have not been systematically investigated." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

FUNCTIONS NOT KNOWN. "Alternative splicing plays a key role in the expansion of proteomic and regulatory complexity, yet the functions of the vast majority of differentially spliced exons are not known." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

BOTH DOMAINS. "While some studies have shown that alternative splicing has a general tendency to avoid protein domains and include disordered regions, other studies have shown that a vast majority of alternatively spliced isoforms could potentially cause significant alterations in regions of the protein structural core." http://www.sciencedirect.com/science/article/pii/S1097276512004844 View in LinkedIn

“It’s a very precious set of data, whether or not it will ultimately hold the secret for a speech prosthetic. It’s truly an extraordinary event.” http://www.wired.com/2016/01/phil-kennedy-mind-control-computer/ View in LinkedIn

EDITING ENTIRE SEGMENTS. "Thus, on the protein level, entire segments can be inserted or deleted through the alternative splicing of protein-coding exons. As a result, it is expected that distinct protein isoforms will often exhibit different functional characteristics.” http://www.sciencedirect.com/science/article/pii/S1097276512004844 View in LinkedIn

SELF-GENERATED DATA. "It’s a very precious set of data, whether or not it will ultimately hold the secret for a speech prosthetic. It’s truly an extraordinary event.” http://www.wired.com/2016/01/phil-kennedy-mind-control-computer/ View in LinkedIn

ADDS TO COMPLEXITY. "Together with gene duplication and recombination, alternative splicing plays a major role in increasing proteome diversity and organismal complexity." http://www.sciencedirect.com/science/article/pii/S1097276512004844 View in LinkedIn