Category: Uncategorized

CHICKEN AND QUAIL. "Hatched chicks with chimeric brains containing cells from both the domestic chicken (Gallus gallus domesticus) and the Japanese quail (Coturnix coturnix japonica) have been produced by transplantation of various regions of the neural tube at the 8- to 15- somite stage." https://lnkd.in/dZP4TNm View in LinkedIn

CHIMERA. "The classical representation of a chimera, such as that described in Homer's Iliad, is a mythical beast bearing the body parts of several different creatures combined into a single animal. The term chimera has a more tangible usage in modern science and medicine, where it indicates organisms comprised of cells from two or more individuals of the same or different species." http://www.sciencedirect.com/science/article/pii/S1934590907000860 View in LinkedIn

NEW HYBRID MODEL. "These human glial-chimeric mice may present a fundamentally new experimental model by which human glial cells, and both normative and pathological species-specific aspects of human glial biology, may now be effectively studied in the live adult brain." https://lnkd.in/dQ9_J77 View in LinkedIn

HAN ET AL. "Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. Long term potentiation (LTP) was sharply enhanced in the human glial chimeric mice, as was their learning, as assessed by Barnes maze navigation, object-location memory, and both contextual and tone fear conditioning." https://lnkd.in/dQ9_J77 View in LinkedIn

HUMAN-MOUSE BRAIN HYBRIDS. "We created human glial-chimeric mice, in which immunodeficient but otherwise normal mice were engrafted neonatally with large numbers of human glial progenitors, resulting in the widespread integration of human glia into the mouse brain." https://lnkd.in/dQ9_J77 View in LinkedIn

BRAIN CELL TRANSPLANT. "In 2013, Xiaoning Han and colleagues in the laboratories of Steven Goldman and Maiken Nedergaard at the University of Rochester Medical Center published a paper examining the possibility of augmenting neural processing ability of one species by surgically transplanting cells from the brain of another “more advanced” species." https://lnkd.in/dAifP-w View in LinkedIn

HUMAN-RAT CHIMERA. "Human neural precursors were then expanded 100-fold prior to intrastriatal transplantation in a rodent model of Parkinson's disease...given the relative safety profile for these human cells and their capacity to extend fibers into the adult rodent brain, they may provide the ideal basis for the repair of other lesions of the CNS." https://lnkd.in/ecGstiF View in LinkedIn

FLY-AMPHIBIAN HYBRID. "Cells of the neural primordia of the Notch mutant of Drosophila melanogaster are transplanted to the neural tube of four amphibian species and two mammalian species. It is shown that cells of the neural primordia of drosophila survive and differentiate in the amphibian and mammalian brain." https://lnkd.in/eTEWncR View in LinkedIn