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NEUROPSYCH. “Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia and often precedes related symptoms. However, mechanistic basis for this association remains unknown.” https://lnkd.in/dacTwM5 View in LinkedIn

ACROSS TAXA. “It is important to note that exposure to light at night is not just a human issue. Many plant and animal species are affected by nighttime light exposure, as lighting from infrastructure strays into the atmosphere creating a general nighttime glow termed light pollution. Unnatural exposure to light at night may have significant ecological implications.” https://lnkd.in/dH6Ha79 View in LinkedIn

DISALIGNMENT. “Humans are unique in that they voluntarily shift their activity period to abnormal times of day, effectively forcing the misalignment between their activity period and their internal circadian clock. This is why disruption of circadian rhythms may have negative effects in both the short (fatigue, insomnia, disorientation) and long term (acceleration of aging, cancer development, functional and inflammatory diseases).” https://lnkd.in/dFZDTVU View in LinkedIn

EXCESS AMBIENT LIGHT. “Shift work during extended time periods (decades) has been reported to provoke serious morbidities, including cardiovascular diseases, metabolic syndrome and malignancies such as breast and colon cancer.” http://www.smw.ch/content/smw-2014-13984/ View in LinkedIn

CIRCADIAN DYSFUNCTION. “Virtually all aspects of human physiology (sleep-wake cycles, body temperature, hormone secretion etc.) are mapped onto 24-hour rhythms. However, modern life styles may frequently disrupt circadian rhythm. This circadian dysfunction is considered to be an important contributory factor to the incidence of a wide range of clinical conditions including sleep disorders, gastrointestinal diseases, metabolic syndrome, inflammation, and even cancer.” https://lnkd.in/dFZDTVU View in LinkedIn

CIRCADIAN DISRUPTION. “Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption. Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans. Importantly, circadian rhythms are most potently synchronized to the external environment by light information and exposure to light at night potentially disrupts circadian system function.” https://lnkd.in/dH6Ha79 View in LinkedIn

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MANY VARIABLES. “Expression alterations of clock genes are associated with key oncogenic pathways, patient survival, tumor stage, and subtype in multiple cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn

LARGE CANCER STUDY. “We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from The Cancer Genome Atlas, Cancer Therapeutics Response Portal, and The Genomics of Drug Sensitivity in Cancer databases.’ https://lnkd.in/dT2NKaY View in LinkedIn