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CYCLIC FUNCTIONS. “The daily patterns of behaviors, including the sleep-wake, rest-activity, and fasting-feeding cycles, influence the daily fluctuations of gastric pH, gastric emptying, gastrointestinal transit time, organ blood flow, liver enzyme activity, and renal function.” https://lnkd.in/dK-Nfr2 View in LinkedIn

CHRONOTHERAPY IN CANCER. “Cancer chronotherapy, based on the circadian activity of the xenobiotic detoxification system and on daytime-dependent drug tolerability, has also delivered its first promising results.” http://www.smw.ch/content/smw-2014-13984/ View in LinkedIn

CHRONOTHERAPY IN RA. “Recently, low-dose glucocorticoid chronotherapy has been shown to yield considerably better results in the treatment of rheumatoid arthritis than conventional glucocorticoid administration. An oral prednisone tablet has been designed to release the drug at 2 a.m., the time of best efficacy. This formulation can be ingested before going to sleep, so that the patient’s sleep does not have to be interrupted.” http://www.smw.ch/content/smw-2014-13984/ View in LinkedIn

COMMUNITY EFFECTS. “In other contexts, the same fate is reinforced among neighboring cells through so-called community effects.” https://lnkd.in/dfCi2dc View in LinkedIn

LATERAL EFFECTS. “At the cellular field level, lineage founder cells may inhibit their direct neighbors that share similar network states from adopting the same fate through a process termed lateral inhibition, often involving the Notch signaling pathway.” https://lnkd.in/dfCi2dc View in LinkedIn

COMPETITIVE FATES. “For example, in the early embryo, allocation of blood and cardiac lineage fates within a common mesodermal field is subject to antagonistic principles, with genetic disruption of TFs important for one fate allowing the other to dominate.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

TUNNEL OF DIMINISHING OPTIONS. “A mainstay concept in developmental biology is that the adoption of a lineage fate invokes a global lockdown of possibilities for alternative fates.” https://lnkd.in/dfCi2dc View in LinkedIn

EXQUISITE REGULATORY INTERACTIONS. “Specification of organ territories or lineages during development requires a progressive restriction of options within cellular fields. This invariably involves a complex reciprocal molecular dialog between neighboring cells.” https://lnkd.in/dfCi2dc View in LinkedIn

SELECTOR GENES. “Others can only do this as part of a TF collective. Certain TFs, termed “pioneer factors,” can find their target sites even in closed chromatin and may “bookmark” these sites during mitosis. It is likely that selector proteins and kernel TFs, as well as proteins that can reprogram cell fate autonomously, have pioneer qualities.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

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