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LATERAL EFFECTS. “At the cellular field level, lineage founder cells may inhibit their direct neighbors that share similar network states from adopting the same fate through a process termed lateral inhibition, often involving the Notch signaling pathway.” https://lnkd.in/dfCi2dc View in LinkedIn

COMPETITIVE FATES. “For example, in the early embryo, allocation of blood and cardiac lineage fates within a common mesodermal field is subject to antagonistic principles, with genetic disruption of TFs important for one fate allowing the other to dominate.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

TUNNEL OF DIMINISHING OPTIONS. “A mainstay concept in developmental biology is that the adoption of a lineage fate invokes a global lockdown of possibilities for alternative fates.” https://lnkd.in/dfCi2dc View in LinkedIn

TIMING MATTERS. “Early clinical trials have suggested significant clinical benefits of specific circadian timing of chemotherapy or radiotherapy by combination with vinblastine, cyclophosphamide, and methotrexate or 5-fluorouracil.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND SURVIVAL. “Disruption of the circadian rhythm is associated with cancer development and poor prognosis. For example, patients with metastatic colorectal cancer who have normal circadian rhythms have a 5-fold higher survival rate than patients with severely disrupted circadian rhythms.” https://lnkd.in/dT2NKaY View in LinkedIn

APPLIED STUDY. “Our study provides a comprehensive analysis of the circadian clock across different cancer types and highlights potential clinical utility of cancer chronotherapy.” https://lnkd.in/dT2NKaY View in LinkedIn

CLINICALLY IMPORTANT GENES. “We identified interactions between clock genes and clinically actionable genes by analyzing co-expression, protein-protein interaction, and chromatin immunoprecipitation sequencing data and also found that clock gene expression is correlated to anti-cancer drug sensitivity in cancer cell lines.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES IN CANCER. “Correlations between expression of clock genes and of other genes in the genome were altered in cancerous versus normal tissues.” https://lnkd.in/dT2NKaY View in LinkedIn

GRID ANALYSIS. “Despite the arrhythmicity caused by double or triple knockdown, the interactive effects of these paralog genes in cancer remain unclear. Here, we compared pathway score in tumor samples with high expression of paralog clock genes in combination versus tumor samples with low expression of paralog clock genes in combination.” https://lnkd.in/dT2NKaY View in LinkedIn