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CANCER AND CLOCK GENES. “Therefore, preventing disruption of the circadian rhythm has the potential to improve the efficacy of cancer therapy. On the other hand, circadian rhythms could be reprogrammed in tumors.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND TUMORS. “Despite the arrhythmicity caused by double or triple knockdown, the interactive effects of these paralog genes in cancer remain to be ascertained. On one hand, loss of circadian homeostasis increases the risk of tumorigenesis in multiple cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK PARALOG GENES. “All 14 core clock genes have at least one paralog gene that may be functionally redundant in clock regulation. Composite knockdown of paralog clock genes may cause more serious consequences than single knockdown.” https://lnkd.in/dT2NKaY View in LinkedIn

PARALOG GENES. “Orthologous and paralogous genes are two types of homologous genes, that is, genes that arise from a common DNA ancestral sequence. Orthologous genes diverged after a speciation event, while paralogous genes diverge from one another within a species.” https://lnkd.in/dUyuDhw View in LinkedIn

TUMOR TRIGGERS. “Dysregulation of clock genes promotes tumorigenesis through mechanisms that include the cell cycle, DNA damage, and metabolism.” https://lnkd.in/dT2NKaY View in LinkedIn

Transformation of leaf form during maturation. It begs the functional question, whose answer is not obvious. View in LinkedIn

TO START AT THE BEGINNING. “To develop cancer chronotherapy, the first crucial step is to understand the roles of clock genes in cancer. The mammalian circadian machinery is controlled by two main transcriptional/translational auto-regulatory feedback loops that involve 14 core clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

NEW WAY FORWARD. “Cancer chronotherapy appears to offer the potential to improve current cancer treatments and to refine the development of new anti-cancer drugs.” https://lnkd.in/dT2NKaY View in LinkedIn

TIMING MATTERS. “Early clinical trials have suggested significant clinical benefits of specific circadian timing of chemotherapy or radiotherapy by combination with vinblastine, cyclophosphamide, and methotrexate or 5-fluorouracil.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND SURVIVAL. “Disruption of the circadian rhythm is associated with cancer development and poor prognosis. For example, patients with metastatic colorectal cancer who have normal circadian rhythms have a 5-fold higher survival rate than patients with severely disrupted circadian rhythms.” https://lnkd.in/dT2NKaY View in LinkedIn