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APPLIED STUDY. “Our study provides a comprehensive analysis of the circadian clock across different cancer types and highlights potential clinical utility of cancer chronotherapy.” https://lnkd.in/dT2NKaY View in LinkedIn

CLINICALLY IMPORTANT GENES. “We identified interactions between clock genes and clinically actionable genes by analyzing co-expression, protein-protein interaction, and chromatin immunoprecipitation sequencing data and also found that clock gene expression is correlated to anti-cancer drug sensitivity in cancer cell lines.” https://lnkd.in/dT2NKaY View in LinkedIn

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DRUGS LINK TO GENES. “We identified 2,059 significant correlation pairs between drug sensitivity and transcriptional expression of clock genes (Figure S7B). Among these, sensitivity to 82 anti-cancer drugs significantly correlated with at least 10 clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

BROAD STUDY. “To further evaluate the potential effects of clock genes on drug response, we analyzed the correlation between drug sensitivity of 265 anti-cancer drugs and transcriptional expression of 51 clock genes across 1,080 cancer cell lines from GDSC using the Z score as described previously.” https://lnkd.in/dT2NKaY View in LinkedIn

DRUG TARGETS. “Many clinically actionable genes are targeted by anti-cancer drugs. Thus, following circadian timing for drug administration may largely improve the efficacy of a drug and reduce its toxicity.” https://lnkd.in/dT2NKaY View in LinkedIn

CLINICAL IMPLICATIONS. “Our results suggest diverse effects of clock genes on clinically actionable genes. Therefore, the significant interactions between clinically actionable genes and clock genes may affect drug responses, and the circadian timing should be necessarily considered in cancer therapy.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENE LINKS. “We observed that 145 of 154 (94.2%) clinically actionable genes have significant correlations, with at least one clock gene in more than five cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn

ACTIONABLE GENES. “To further understand clinical implications of the clock timing, we examined correlations between transcriptional expression of clock genes and 154 clinically actionable genes (targets of FDA-approved drugs or their related marker genes), including 135 genes for targeted therapy and 19 target genes for immunotherapy across all cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn