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CLINICAL CORRELATES. “We further showed that transcriptional dysregulation of clock genes is strongly associated with patient survival, tumor stage and subtype.” https://lnkd.in/dT2NKaY View in LinkedIn

DYSREGULATION. “We revealed disruption of circadian rhythms across patient samples by showing significantly reduced number of genes correlated to clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

MULTIPLE PATHWAYS. "Aquatic plants are an extremely heterogeneous assemblage of species that survive in similar habitats but as a result of fundamentally different evolutionary pathways." https://lnkd.in/dAT9Bid View in LinkedIn

YIN YANG. “Our results suggested several clock genes may function as oncogenes...while several other clock genes may function as tumor suppressors.” https://lnkd.in/dT2NKaY View in LinkedIn

MULTIPLE PATHWAYS. "Aquatic plants are an extremely heterogeneous assemblage of species that survive in similar habitats but as a result of fundamentally different evolutionary pathways." https://lnkd.in/dAT9Bid View in LinkedIn

ENORMOUS SCOPE. “In this study, we utilized multi-dimensional omics data and clinical data across 32 cancer types from TCGA, and pharmacogenomic data from CTRP and GDSC. We revealed global alterations of clock genes at transcriptional, genetic, and epigenetic levels.” https://lnkd.in/dT2NKaY View in LinkedIn

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MASSIVE CORRELATIONS. “Among 481 compounds, we identified 329 compounds that have at least one significant correlation with clock genes, with 3,577 significant correlation pairs (Figure S7D). We found 163 compounds that showed significant correlation with at least 10 clock genes (Figure S7E), and 76 drugs are shared between the GDSC and CTRP databases. Among them, 53 drugs in both CTRP and GDSC have at least one pair that significantly correlates with clock genes. These results show the consistency of circadian effects on drug response.” https://lnkd.in/dT2NKaY View in LinkedIn

MULTIPLE PATHWAYS. "Aquatic plants are an extremely heterogeneous assemblage of species that survive in similar habitats but as a result of fundamentally different evolutionary pathways." https://lnkd.in/dAT9Bid View in LinkedIn

MULTIPLE EVENTS. "The transition to an aquatic life has been achieved by only 2% of the approximately 350,000 angiosperm species. Nevertheless, the evolutionary invasion of aquatic environments by terrestrial angiosperms is estimated to represent 50-100 independent events." https://lnkd.in/dh26Z3X View in LinkedIn