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SO ENDS this first of two weekends on the return to aquatic life of some plants. This is akin to the journey that whales took, returning to the sea after leaving the sea for dry land, equally challenging both anatomically and metabolically. Evolution has numerous examples of similar reversals, classically, flightless birds. With an engine that generates constant diversity in search of a purpose, evolution has this ability sometimes to go one step forward and two steps back. View in LinkedIn

NEW TREATMENT AVENUES. “There is an urgent need to consider the disruption and/or reprogramming of circadian rhythm in cancer treatment.” https://lnkd.in/dT2NKaY View in LinkedIn

CIRCADIAN DISRUPTION IN CANCER. “Our study showed a global disruption of circadian rhythms in both patient samples and cancer cell lines. In cancer patients, number of genes correlated to clock genes is largely reduced, suggesting the disruption of circadian rhythm.” https://lnkd.in/dT2NKaY View in LinkedIn

Marly limestone, common around Vic in Catalonia. An example of the unsolved material complexity mixed with archaic terms in geology. View in LinkedIn

MULTILEVEL STUDY. “Our comprehensive analysis of clock genes at the transcriptional, genetic, and epigenetic level is the crucial step to understand the functional roles of clock genes across different cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn

OUTCOME PREDICTIONS. “Despite the relatively low mutation frequency of clock genes, combinations of mutations in multiple clock genes may provide prognostic value.” https://lnkd.in/dT2NKaY View in LinkedIn

CENTRAL ROLE. “We observed that paralog clock genes could play synergistic or different roles to alter oncogenic pathways, further suggesting a complex regulation of clock transcriptional loops.” https://lnkd.in/dT2NKaY View in LinkedIn

CONFIRMED FINDINGS. “We observed cancer-specific patterns for several genes across different cancer types, consistent with previous finding that genetic elements may play different roles in different tumor environments. Furthermore, the expression changes in clock genes are highly associated with the activity of oncogenic pathways.” https://lnkd.in/dT2NKaY View in LinkedIn

EXPANDING KNOWLEDGE. “Supporting the development of cancer chronotherapy, we revealed pervasive transcriptional dysregulation of clock genes across different cancer types, including changes in clock genes that are not well-characterized.” https://lnkd.in/dT2NKaY View in LinkedIn