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ELEPHANT IN THE ROOM. “Helical flexibility as a mechanism to either generate structural recognition signals along the DNA molecule or regulate superhelical topology was not discussed extensively.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

HYPOTHETICAL FUNCTION. “Left-handed double helical DNA regions might be anticipated to facilitate replication fork movement and chain separation during DNA replication.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

LEVOROTATORY VARIANT. “Although there was discussion of the possibility of left-handed helices, especially shortly after the double helix formulation, there were very few systematic studies of left-handed helices published during the next decade or so.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

THE VARIANTS. “The greater wealth of diffraction data seen in the A pattern made it possible to get more information. The relative ease with which it slipped into the B pattern reinforced the idea that these were two conformational variants; it was found that both patterns could be fitted by a right-handed double helix.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

METHODOLOGICAL LIMITATIONS. “Considerable attention was paid to the fact that under certain conditions alternative conformational variants were seen. The most important of these was the A-DNA pattern which originally was produced by air-dried fibers.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn