linkedin post 2021-05-29 03:44:15

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DARK MATTER. “Now, scientists have created the largest ever map of this mysterious substance – and it could imply that there’s something wrong with Einstein’s theory of relativity. They have also mapped the location of vast cosmic voids where the conventional laws of physics may not apply.” Read the last sentence again. https://lnkd.in/dPsJYV3 View in LinkedIn
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linkedin post 2021-05-31 03:58:37

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THE CONJECTURE. “In particular, as emphasized by Bekenstein, an entropy bound of the form ensures that the generalized second law of thermodynamics is respected in a physical process in which a spherical body with negligible self-gravity is captured by a black hole.” https://lnkd.in/d3sfhP6 View in LinkedIn
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linkedin post 2021-05-30 05:39:05

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INTUITIVE KNOWLEDGE IS NECESSARY. “The basic fact being stressed is that there are frequent situations in mathematics in which a formal conviction, derived from a formally certain proof, is NOT associated with the subtle feeling of “It must be so”, “I feel it must be so”. (Fischbein, 1982) https://lnkd.in/dfVcgbr View in LinkedIn
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linkedin post 2021-05-30 05:37:34

linkedin post 2021-05-30 05:37:34

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SO ENDS this first of two weekends on an historic paper on DNA chirality. There are some items that we take for granted, but on closer scrutiny, it was based on assumptions required because the methodology did not have sufficient precision. And so was the case with the assumed handedness of DNA. Other-handed DNA proved not only to exist but have relevance in disease. https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-05-30 05:36:59

linkedin post 2021-05-30 05:36:59

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THE SURPRISE. “The resultant structure was quite unusual. It was a left-handed helix. However, it was not a simple left-handed helix, but one in which the alternating purine-pyrimidine sequence of the oligonucleotide was used in a unique way.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-05-30 05:35:08

linkedin post 2021-05-30 05:35:08

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FIRST MILESTONE. “The first visualization of the double helix at atomic resolution occurred almost ten years ago with the solution of the structures of rApU and rGpC which were found to form right-handed double helical fragments of the type which had been anticipated for RNA molecules.” (1982). https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-05-30 05:33:56

linkedin post 2021-05-30 05:33:56

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TECHNICAL RESOLUTION. “Unlike fiber diffraction patterns, single crystals can diffract to a very high resolution and they produce very large numbers of reflections or experimental measurements. This in turn makes it possible to solve the structures and observe fine details of DNA conformation in which very little or no interpretation is required.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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