linkedin post 2021-06-06 03:53:27

linkedin post 2021-06-06 03:53:27

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THE DETAILS. “One of the main features of Z-DNA, however, is that it twists the double helix in the opposite sense of B-DNA. Negative supercoiling stabilizes Z-DNA. However, if a large segment of Z-DNA then converts back into B-DNA, it will impart considerable twist to the DNA and further increase its negative supercoiling. A change in the supercoiling would be evident not only nearby but also at considerable distance away from the DNA.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-06 03:50:32

linkedin post 2021-06-06 03:50:32

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THE BACKGROUND. “Antibodies against nuclear components have been found in certain pathological states. In the autoimmune disease systemic lupus erythematosus a variety of antibodies have been identified against various nucleic acid components.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-06 03:48:49

linkedin post 2021-06-06 03:48:49

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SURPRISE FINDING. “It has been shown that Z-DNA can exist in the same molecule with B-DNA. This was shown by cloning oligo(dG-dC) into plasmids and then isolating segments containing both the plasmid DNA and the oligo(dG-dC).” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-06 03:47:33

linkedin post 2021-06-06 03:47:33

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THE FACTORS. “Because of increased phosphate-phosphate repulsion forces the left-handed helical structure is inherently less stable than B-DNA in a physiological salt solution. In view of the equilibrium between the two forms, it is clear that a number of components in the environment could stabilize Z-DNA.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-09 03:50:09

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SHANNON VS BOLTZMANN. “The two entropies have two salient differences, though. First, the thermodynamic entropy used by a chemist or a refrigeration engineer is expressed in units of energy divided by temperature, whereas the Shannon entropy used by a communications engineer is in bits, essentially dimensionless. That difference is merely a matter of convention.” https://lnkd.in/draqjTW View in LinkedIn
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