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THE FACTORS. “Because of increased phosphate-phosphate repulsion forces the left-handed helical structure is inherently less stable than B-DNA in a physiological salt solution. In view of the equilibrium between the two forms, it is clear that a number of components in the environment could stabilize Z-DNA.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

GENE REGULATION. “We suggest that the conformation of the DNA may be used by nature in regulating gene expression. Of course, this represents a description of molecular machinery but it does not describe in detail those events which are in control of the Z-DNA forming ability of a particular segment of DNA.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

TRANSCRIPTIONAL CONTROL. “What we have outlined here is a speculative model of the role of Z-DNA involving the regulation of transcription of genes which are close to the Z site (proximal) or further away from the Z site (distal).” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

THE DETAILS. “One of the main features of Z-DNA, however, is that it twists the double helix in the opposite sense of B-DNA. Negative supercoiling stabilizes Z-DNA. However, if a large segment of Z-DNA then converts back into B-DNA, it will impart considerable twist to the DNA and further increase its negative supercoiling. A change in the supercoiling would be evident not only nearby but also at considerable distance away from the DNA.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn