Category: Uncategorized

DNA VACCINE FOOTNOTE. This approach is actually not new, and was an unwanted byproduct of early gene therapy. Pharma has largely taken a backseat approach to DNA vaccines, and frankly it takes a luminary like Venter and a forward looking agency like DARPA to propel it into the limelight. At last. View in LinkedIn

NEXT GENERATION DNA VACCINES II: "This approach offers a number of potential advantages over traditional approaches, including the stimulation of both B- and T-cell responses, improved vaccine stability, the absence of any infectious agent and the relative ease of large-scale manufacture." http://www.who.int/biologicals/areas/vaccines/dna/en/ View in LinkedIn

NEXT GENERATION DNA VACCINES I: "A radically new approach to vaccination has been developed. It involves ... a plasmid containing the DNA sequence encoding the antigen(s) against which an immune response is sought, and relies on the in situ production of the target antigen." http://www.who.int/biologicals/areas/vaccines/dna/en/ View in LinkedIn

NEW VS OLD METHOD II. "... Teams at JCVI, are world leaders in the design and construction of such large gene constructs. It took the team only approximately 10 hours to construct and assemble the synthetic ... cassettes... This method enables the rapid and accurate conversion of digital sequence information to biologically active DNA." http://www.jcvi.org/cms/press/press-releases/full-text/article/research-team-publishes-new-methods-for-synthetic-generation-of-influenza-vaccines/#sthash.aepwVBDD.dpuf View in LinkedIn

NEW VS OLD METHOD I. "In the traditional approach to vaccine development, an influenza virus is cultured and grown in chicken eggs. The synthetic genomics approach starts with virus genome sequence data in the computer ... it is still difficult to rapidly and accurately construct large pieces of DNA, large genes and whole genomes." http://www.jcvi.org/cms/press/press-releases/full-text/article/research-team-publishes-new-methods-for-synthetic-generation-of-influenza-vaccines/#sthash.aepwVBDD.dpuf View in LinkedIn

SUPER-FAST VACCINE FOR PANDEMICS II. "The team concludes that this is a novel and accurate method that could enable a more rapid pandemic response and yield a more reliable supply of better matched seasonal and pandemic vaccines than are currently available." (Craig J Venter). http://www.jcvi.org/cms/press/press-releases/full-text/article/research-team-publishes-new-methods-for-synthetic-generation-of-influenza-vaccines/#sthash.aepwVBDD.dpuf View in LinkedIn

SUPER-FAST VACCINE FOR PANDEMICS I. "In a timed proof of concept this team demonstrated that in just four days and four hours they could accurately construct robust synthetic vaccine viruses for use in influenza vaccine development."(Craig J Venter). http://www.jcvi.org/cms/press/press-releases/full-text/article/research-team-publishes-new-methods-for-synthetic-generation-of-influenza-vaccines/#sthash.aepwVBDD.dpuf View in LinkedIn

TELEPORTING DNA FOR QUICK VACCINES PART II. "Novartis is already scaling up the vaccine before we’ve had a single outbreak in the U.S. That is the opposite of what happened with H1N1 when we didn’t have a vaccine until two months after the pandemic had peaked." (Craig J Venter). http://lnkd.in/dB4m5rE View in LinkedIn

TELEPORTING DNA FOR QUICK VACCINES PART I. "We are now engaged in finding new ways to head off pandemics by being able to read the code of flu strains and very rapidly produce vaccines to stop them. We received the sequence from them in digital form by email and converted it back into DNA to produce the vaccine in about 10 hours." (Craig J Venter). http://lnkd.in/dB4m5rE View in LinkedIn

DARPA SEEKS FAST DNA VACCINES. "After losing more than 1 million service days during the Iraq and Afghanistan wars to severe diarrhea in troops, the Defense Advanced Research Projects Agency wants to combat the problem by making drugs based on nucleic acids such as DNA rather than the weakened or dead proteins typically used in vaccines."" " http://lnkd.in/dmAkSWM View in LinkedIn