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CLOCK METABOLISM. “Given that the clock is intimately involved in regulating metabolism in peripheral tissues, and the majority of metabolites in liver and serum are controlled in a cyclic manner, the intersection of cancer metabolism and its control by the circadian clock is an area of active investigation.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

TIMING PACEMAKER. “Collectively these findings implicate a critical signaling axis that coordinates the central pacemaker with peripheral circadian transcription and metabolism, though the implications of these findings in humans remains unresolved (Box 2).” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

LAG MECHANISM. “Jet lag operates by disrupting both circadian gene expression programs as well as circadian metabolism in the liver, and central to this rewiring is an induction of hepatic cholesterol and bile acid levels, which activate the oncogenic program of the nuclear receptor constitutive androstane receptor (CAR), and downstream activation of β-catenin.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

JET LAG. “Recent laboratory data have shed light on the molecular mechanisms of circadian disruption through jet lag and its link with tumorigenesis. Long-term jet lag initiates a program of nonalcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis, fibrosis, and eventually HCC in mice.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

EPIGENETIC SILENCERS. “Moreover, in 126 cases of several types of hematologic malignancies, Bmal1 gene silencing due to CpG promoter methylation was found in 19.7% of diffuse large B cell lymphomas, 33.3% of acute lymphocytic leukemias, and 19.2% of acute myeloid leukemias.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

EPIGENETIC FINGERPRINT. “On a genome-wide scale, 5,409 CpG sites were found to be differentially methylated in day-time versus night-time shift workers, and a remarkable 66% of these loci were hypermethylated. Similarly, CpG methylation of the PER1, PER2 and PER3 promoters was found to correlate with changes in protein expression in 50% of breast tumors versus normal tissue taken from the same patient.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

THE QUESTION. “Why were the two U-processes each dominated by superpositions moving outward from the Big Bang along the time dimension? Perhaps because at the Planck time, or any very early time, superpositions evolving backward in time would have very little potential duration, compared to many very long potential durations away from the origin.” https://lnkd.in/gDaxUYAS View in LinkedIn

EPIGENETIC METHYLATION. “For instance, in female shift workers from a prospective cohort in Denmark, DNA methylation studies have found genome-wide alterations to cancer-specific and circadian loci, including estrogen receptor α (ESR1) and the circadian genes clock (CLOCK) and cryptochrome 2 (CRY2).” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ORIGINS. “As part of this initial R-process which produced the Big Bang, the simplest assumption is that our universes have an R-process which proceeds indefinitely, to produce a single reality, which foliated spacetime in a double plane of simultaneity across the whole of the tiny universes at plus and minus the Planck time.” https://lnkd.in/gDaxUYAS View in LinkedIn

EPIGENETIC FACTORS. “Epidemiological studies indicate that disruption of circadian rhythms in humans is associated to increased cancer risk (see above). In addition, pilot data now suggest that shift work can also regulate the epigenetic landscape, which could likely be a mechanism by which circadian gene expression is altered.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn