Category: Uncategorized

FUTURE WORK. “Therefore, further investigation is required to determine the role of nutritional inputs on circadian metabolism and tumorigenesis.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

METABOLIC FACTORS. “Also, metabolomics analyses in human serum, plasma, and skeletal muscle have identified major populations of rhythmic metabolites over the circadian cycle.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ALTERNATE PATHWAY. “A similar example exists with nitrogen repurposing of ammonia waste that was reported to be recycled into central amino acid metabolism through the enzymatic activity of glutamate dehydrogenase in breast cancer cells.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCK TRIGGERS. “Studies in mouse models as well as in human subjects have shown the remarkable effect of specific dietary regimes, such as a high-fat diet, as well as that of time-restricted feeding on the circadian clock.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

METABOLIC SWITCHING. “Clinical and laboratory studies have provided evidence that NSCLC exhibits metabolic heterogeneity in fuel utilization and, while glucose oxidation is metabolically imperative, lactate can also be used as a carbon source.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RECYCLED WASTES. “Importantly, evidence also suggests that tumor-derived waste can be repurposed and subsequently utilized as fuel for tumors.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

UNKNOWNS. “Further investigation is needed to better understand how the clock controls metastasis in different cancer types and how this tumor-dependent secretome may differ because of disease profile.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCKS AND CANCER. “These findings suggest a crosstalk between the circadian clock and cancer cells through the tumor-derived macroenvironment and underscore the ability of canonical and noncanonical clock components to regulate a metastatic secretome.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

QUESTION. “Can the circadian clock feedback and regulate properties of tumorigenesis? If so, what are these circadian cues that modulate cancer progression systemically?” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

Very early evidence of the use of glasses (Lyon Art Museum). View in LinkedIn