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SERIOUS CROSSTALK. “Bacteria use quorum sensing to coordinate certain behaviors such as biofilm formation, virulence, and antibiotic resistance, based on the local density of the bacterial population. Quorum sensing can occur within a single bacterial species as well as between diverse species.” http://en.m.wikipedia.org/wiki/Quorum_sensing View in LinkedIn

POTENTIAL ANTIBIOTIC ALTERNATIVE. "With the ongoing emergence of antibiotic-resistant pathogens, there is a current need for development of alternative therapeutic strategies. Overall, the evidence suggests that QSI therapy may be efficacious against some, but not necessarily all, bacterial pathogens." https://lnkd.in/d8iYCZj View in LinkedIn

MEDICAL ANGLE OF QUORUM SENSING. "Quorum-quenching mechanisms are widely conserved in many prokaryotic and eukaryotic organisms. These naturally occurring quorum-quenching mechanisms appear to play important roles in microbe–microbe and pathogen–host interactions and have been used." https://lnkd.in/dp7sxG6 View in LinkedIn

QUORUM QUENCHING. "Over the last decade, many microbes capable of degrading QS molecules have been documented. In some cases, QS-bacteria could degrade their own autoinducers to terminate quorum-sensing activities. A limited number of QQ enzymes that interfere with bacterial QS molecules are known, although the general mechanisms of the QS system are well understood." https://lnkd.in/dEGPGEj View in LinkedIn

DIVERSE QUORUM LANGUAGE. "Eukaryotes and prokaryotes have evolved diverse signalling mechanisms to detect and respond to each other. Although bacterial QS signal molecules have largely been considered as effectors of prokaryotic gene expression, they are bioactive molecules which can modify the behaviour of fungal, plant and animal cells." http://mic.sgmjournals.org/content/153/12/3923.full View in LinkedIn

QS CONTROLLED POST-HARVEST OROCESSES. "Er. carotovora causes the post-harvest soft rotting of many vegetable crops including potato, carrot and green pepper. The virulence of this plant pathogen depends on the synthesis and secretion of a number of exoenzymes including pectinases, cellulases and proteases. Expression of the genes coding for these plant cell wall degrading enzymes is controlled by QS." http://mic.sgmjournals.org/content/153/12/3923.full View in LinkedIn

SIGNIFICANT GENETIC COMMITMENT. "A significant portion of a bacterial genome (4%–10%) and proteome (20% or more) can be influenced by quorum signaling, which suggests that quorum sensing is a mechanism used by pathogenic bacteria not only to modulate virulence factor production but also to adapt to the metabolic demands of living in communities." http://cid.oxfordjournals.org/content/47/8/1070.long View in LinkedIn

SIGNAL ATTRITION. "The term quorum sensing does not, however, adequately describe all situations where bacteria employ diffusible chemical signals. The size of the quorum, for example, is not fixed but will vary according to the relative rates of production and loss of signal molecule, i.e. it is dependent on the prevailing local environmental conditions." http://rstb.royalsocietypublishing.org/content/362/1483/1119 View in LinkedIn

GAMING THE COMMON GOOD. "The cooperative population is exposed to exploitation by cheaters, i.e., mutants who contribute less or nil to the effort but fully enjoy the benefits of cooperation. The communication system is also vulnerable to a different type of cheaters (“Liars”) who may produce the QS signal but not the exoproduct, thus ruining the reliability of the signal. https://lnkd.in/dT8bNGS View in LinkedIn

COMMON GOOD ACTIONS. "Bacterial cooperation may take the form of the excretion of “public goods”: exoproducts such as virulence factors, exoenzymes or components of the matrix in biofilms, to yield significant benefit for individuals joining in the common effort of producing them." https://lnkd.in/dT8bNGS View in LinkedIn