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AMNESIC SHELLFISH POISONING (ASP): main symptoms after a few months: 12/14 severe patients had severe anterograde memory deficits and neuropathies. No surprise given the central role of glutamate receptors in domoic acid poisoning. https://lnkd.in/ezgTzXm View in LinkedIn

RED TIDE. August 5, 2015: news flash. "A vast bloom of toxic algae off the west coast is denser, more widespread, and deeper than scientist feared even weeks ago..." https://lnkd.in/eFVnC_b View in LinkedIn

AMNESIC SHELLFISH POISONING (ASP): main symptoms of domoic acid poisoning: acute: headache, seizures, hemiparesis, opthalmoplegia, and arousal abnormalities." https://lnkd.in/ezgTzXm View in LinkedIn

FRAGMENT IN NATURE this weekend is all about the complex and important family of glutamate receptors. There are three structurally-related molecules that act on these L-glutamate receptors, and all are associated with pathology and toxicity. The central linking molecule dramatically came to light in 1987 following a public health catastrophe in Prince Edward Island, Canada. View in LinkedIn

GLUTAMATE RECEPTORS. "One of the major functions of glutamate receptors appears to be the modulation of synaptic plasticity, a property of the brain thought to be vital for memory and learning." The main target of domoic acid. https://lnkd.in/eMAKUzc View in LinkedIn

PROCESSED FOOD. "Food proteins exposed to alkali treatment processes or to lengthy heat treatment contain considerable concentrations of amino acids derived from racemisation," ie: the conversion of healthy L-amino acids to generally useless or harmful D-amino acids. https://lnkd.in/eNSAN8h View in LinkedIn

GLUTAMATE RECEPTORS. "Glutamate (Glutamic acid) is the most prominent neurotransmitter in the body, and it is the main excitatory neurotransmitter, being present in over 50% of nervous tissue." https://lnkd.in/eMAKUzc View in LinkedIn

DOMOIC ACID. "Domoic acid is a kainic acid analog neurotoxin that causes amnesic shellfish poisoning. It is produced by algae and accumulates in shellfish, sardines, and anchovies" through the ingestion of certain algal blooms. "Exposure to the biotoxin affects the brain, causing seizures, and possibly death." https://lnkd.in/ea6_24c View in LinkedIn

MECHANISM OF ACTION. "Activation of AMPA/KA-Rs (direct) and NMDA-Rs (indirect) can cause apoptotic and necrotic neuronal cell death." https://lnkd.in/e3pZBba View in LinkedIn

MECHANISM OF ACTION. Domoic acid "activates the AMPA/KA-Receptor, which induces increased levels of intracellular Ca2+ which, in turn, causes glutamate release that subsequently activates the NMDA-Receptor." https://lnkd.in/e3pZBba View in LinkedIn