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MODEL NANO-MOTOR. "Overall rotatory motor functions and universal presence makes F1F0 ATP synthase a front runner base model in the development of nanomotors for nanomedicine usage." https://lnkd.in/eTYm4q6 View in LinkedIn

PROGNOSTIC. "Surprisingly, colon and breast cancer patients with high tumor expression of IF1 have a better prognosis in terms of time of disease relapse which suggests that cancer cells with a low expression of IF1 should be more likely to metastasize. The molecular bases of this paradox are presently unknown." https://lnkd.in/ejS5qyU View in LinkedIn

NATURAL INHIBITOR. "IF1 has been described in mammals, birds, amphibious, nematodes, yeast and plants and shows considerable sequence identity among various eukaryotes." https://lnkd.in/ejS5qyU View in LinkedIn

MICROTUBULE INFO PROCESSING. "Conventional neuronal-level approaches based on axonal firings and synaptic transmissions (10(11) neurons/brain, 10(3) synapses/neuron, 10(2) transmissions/s/synapse) give the same 10(16) operations per second for the entire brain!" https://lnkd.in/e2cr6ar View in LinkedIn

NATURAL INHIBITOR. "IF1 is a master regulator of energy metabolism in cancer and in stem cells. In mitochondria, ATP hydrolysis by the H+-ATP synthase is inhibited by the ATPase Inhibitory Factor 1 (IF1) that reversibly binds to the enzyme." https://lnkd.in/ejS5qyU View in LinkedIn

MICROTUBULE (MT) "automata based on tubulin dipoles in hexagonal lattices show high capacity integration and learning. Assuming 10(9) binary tubulins per neuron switching at 10 megahertz (10(7)) gives a potential MT-based capacity of 10(16) operations per second per neuron." https://lnkd.in/e2cr6ar View in LinkedIn

TARGET INHIBITORS. "So far approximately twelve binding sites for a variety of natural and synthetic inhibitors have been identified on ATP synthase. Thus the use of ATP synthase as a potential molecular drug target seems straight forward." But despite this obvious target we have no sweeping successes. https://lnkd.in/eTYm4q6 View in LinkedIn

CONSCIOUSNESS HYPOTHESIS. A "highly controversial suggestion by Roger Penrose and Stuart Hameroff that quantum behaviour of protein filaments called microtubules is responsible for the computational capability of the human mind." Important article for a later theme on brain uploading. https://lnkd.in/eJrZRx4 View in LinkedIn

OXIDATIVE STRESS. "The overproduction of ROS in response to metabolic stress triggered by hypoxia or chemotherapy promotes an oxidative stress that has been invariably linked to multiple pathologies including neurodegenerative diseases, diabetes, cancer and premature aging." https://lnkd.in/ejS5qyU View in LinkedIn

SIR ROGER PENROSE, Emeritus Professor of Mathematics at Oxford University on Twisters and Quantum non-locality. Do your head in. https://lnkd.in/eR3iu8S View in LinkedIn