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MICROBIAL STRATEGY. "Microbial pathogens may improve their ability to persist in infected hosts by causing the death of cells required for host defense. Although some intracellular pathogens may employ strategies to prevent cell death during pathogen replication, escape and dissemination to new host cells may eventually require cell lysis." https://lnkd.in/eEUp2nB View in LinkedIn

PYROPTOSIS. "The inflammasome activation causes a rapid, pro-inflammatory form of cell death called pyroptosis." Another cell suicide mechanism, different from apoptosis. https://lnkd.in/eSuQQy4 View in LinkedIn

FRAGMENT FROM NATURE this weekend continues with the inflammasome. The molecular mechanisms of action of inflammasones are well known but the intersection of different mechanisms and causes of cell death are emerging as complex and sophisticated, and the associations with diseases are proving widespread. View in LinkedIn

DIETARY DNA. "Animal feeding studies have demonstrated that a minor amount of fragmented dietary DNA may resist the digestive process and there are sporadic reports in the literature claiming that orally administered small fragments of bacterial DNA or plant RNA can transgress the intestinal barrier." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069805 View in LinkedIn

FOOD GENES TO BLOOD. "Complete Genes May Pass from Food to Human Blood. Based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069805 View in LinkedIn

OLD DOGMA. "According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069805 View in LinkedIn

DNA IN FOOD. "Depending on the extent of processing, various fractions of DNA molecules of varying size may be present in the consumed product, even in processed food such as corn chips and chocolate." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069805 View in LinkedIn

ATP RECEPTOR. "This receptor has a special place in inflammasome biology because its stimulation is still used as one of the most potent and reliable means to activate the NLRP3 inflammasome. The P2X7R is ideally suited to respond to unusual, pathologic ATP tissue levels because of its very high EC50 for ATP (between 100 and 300 μM) and lack of desensitization. These features allow P2X7R to open most frequently when extracellular ATP is elevated above physiologic levels." https://lnkd.in/eNNPn5D View in LinkedIn

FLOATING IN A SEA OF DNA. "We are constantly exposed to foreign DNA from various sources like benign or malicious microbes in and on our body, pollens in the inhaled air and as the largest amount with the daily food supply. DNA molecules are ubiquitous in large numbers in all raw and unprocessed food." https://lnkd.in/ebnSqhQ View in LinkedIn

ATP ALARM SIGNAL "ATP itself is a very efficient extracellular distress signal because, with the extracellular level normally very low, even minute leaks can increase the pericellular concentration several fold." https://lnkd.in/eNNPn5D View in LinkedIn