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CASE OF NON-FUNCTIONAL TRANSFER. "Mulberry miRNAs are convincingly transferred to the silkworm orally and no physiological process associated with the miRNAs was demonstrable. The results provided a new aspect of cross-kingdom miRNA transfer." https://lnkd.in/ecyjYr4 View in LinkedIn

LONG DISTANCE SIGNALS. "Cross-kingdom RNAi events demonstrate that gene silencing signals can travel extracellularly over long distances and, in terms of plant–microbe interaction, across plant and pathogen cell walls, membranes, cuticular layers and other cellular boundaries. However, the underlying mechanisms of trafficking of RNAi signals still remain enigmatic." https://lnkd.in/evpzgrd View in LinkedIn

"CROSS-KINGDOM RNAi describes the phenomenon in which a donor organism produces an RNAi trigger that moves into a recipient organism and causes gene silencing. Cross-kingdom RNAi occurs during host plant–pathogen interaction, and can take place in both directions: (i) sRNAs produced by a pathogen to be delivered into host cells to silence host genes; and (ii) a host-produced gene silencing trigger to suppress pathogen gene(s)." (sRNA = smallRNA or microRNA; RNAi = RNA interference) https://lnkd.in/evpzgrd View in LinkedIn

After the leaks today showing just what it really stands for, this could be the end for TTIP. At last!! View in LinkedIn

LEAVES AND ORGANS LINKED. "miRNAs regulate the growth and development of root, leaf, and flower in plants, and have important roles in the development of organs in animals." https://lnkd.in/ecyjYr4 View in LinkedIn

PLANT HOMOLOG AND TUMORS. "We found that Western donor sera contained the plant miRNA miR159, whose abundance in the serum was inversely correlated with breast cancer incidence and progression in patients. Oral administration of miR159 mimic significantly suppressed the growth of xenograft breast tumors in mice. These results demonstrate for the first time that a plant miRNA can inhibit cancer growth in mammals." https://lnkd.in/e_qsx9z View in LinkedIn

HOMOLOGS ACROSS KINGDOMS. "Some of the predicted plant miRNAs have functional homology to their mammalian counterparts and regulated human genes when they were transfected into cell lines." https://lnkd.in/eBr8GUp View in LinkedIn

DIET AND ENVIRONMENT. "The influence of diet and environment on human health has been known since ages. Plant-derived natural bioactive compounds (phytochemicals) have acquired an important role in human diet as potent antioxidants and cancer chemopreventive agents." All Epigenetic phenomena. https://lnkd.in/eQPpbvk View in LinkedIn

"A NON-CODING RNA (ncRNA) is a functional RNA molecule that is transcribed from DNA but not translated into proteins. Epigenetic related ncRNAs include miRNA, siRNA, piRNA and lncRNA." http://www.whatisepigenetics.com/non-coding-rna/ View in LinkedIn

BAT ECHOLOCATION. "Divergent clades of echolocating bats seem to have undergone convergent amino acid replacements in several genes implicated in hearing. Furthermore, some candidate hearing genes also show parallel changes in echolocating bats and whales, again suggesting roles in high-frequency hearing." https://lnkd.in/epGtvrz View in LinkedIn