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FIRST TYPE OF EDITING. "We can identify two complementary kinds of natural genome editing: (i) long lasting and stable inherited alterations of the cellular DNA genomes by persistent viral infections that alter genetic host identity." https://lnkd.in/eJg7ubh View in LinkedIn

FRAGMENT FROM NATURE features interactomes. The last two weekends focused on gene quantity and the immense protein space. Now we see how it all comes together as proteins form larger associations and interactions, synergistically adding to complexity and functional capability. This connects the genotype to the phenotype. And it all needs coordination on a vast scale. View in LinkedIn

VIRAL EDITOR'S PEN. "There are some indicators that viruses and viral-derived elements are the agents that edit the genome in host organisms, such as the non-lytic but persistent colonization of prokaryotes and eukaryotes by viral agents." https://lnkd.in/eJg7ubh View in LinkedIn

ALTERNATIVE SPLICING. "In complex organisms, especially in mammals, before the transcript is processed to the final mRNA for translation into protein, natural genetic engineering occurs which we call alternative splicing." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

OUTSTANDING REVIEW on viral genome editing, and the source of a number of upcoming quotes. Worth a close read. https://lnkd.in/eJg7ubh View in LinkedIn

GENETIC TEXT EDITORS. "Three RNA assemblages are currently known to play vital roles in editing genetic text as a read-and-write medium." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

GENOME EDITING IS IMPORTANT. "There is growing evidence that natural genome-editing competences of viruses are essential for the evolution of the eukaryotic nucleus, the adaptive immune system and the placental mammals." https://lnkd.in/e-pJFM6 View in LinkedIn

"RIBOSOMAL RNA components are catalytically active in polypeptide synthesis and are of major importance in every living cell." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

PALINDROMIC PROTECTION. "Microbial cells are protected from viral infections by clustered regularly interspaced short palindromic repeats that act together with proteins to cleave single-stranded RNA...These repeats are therefore evolutionarily very old." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

GENOMIC REGULATORS. "Reverse transcribed repetitive elements regulate genome organization." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn