Category: Uncategorized

CLINICAL SIGNS AND MODULES. "Characterization of clinical signs in the human interactome. Many diseases are related by shared associated molecules and pathways, exhibiting comorbidities and common phenotypes, an indication of the continuous nature of the human pathological landscape. We found that clinical signs are reflected as modules at the molecular network level, to at least to the same extent as diseases." https://lnkd.in/ebPrQCK View in LinkedIn

"Module exchange occurs at frequencies higher than or equal to the mutation rate, and it thus offers an enhanced genetic adaptation efficiency relative to evolution by linear descent." http://mmbr.asm.org/content/75/3/423.full View in LinkedIn

ACTIVE INTERACTIONS. "The new interactome map lends support to a long-held suspicion that proteins implicated in cancer participate in disproportionate numbers of interactions with other proteins. As scientists sequence tumor genomes, more extensive knowledge of these protein-protein interactions could help to distinguish “driver” mutations that cause cancer from “passenger” mutations that are simply along for the ride." https://lnkd.in/etGh98E View in LinkedIn

THE MODULAR THEORY "of phage evolution states that evolution takes place through the transfer of exchangeable units that might consist only of protein domains rather than of whole genes or transcriptional units. Module exchange occurs at frequencies higher than or equal to the mutation rate, and it thus offers an enhanced genetic adaptation efficiency relative to evolution by linear descent." https://lnkd.in/enWfaU4 View in LinkedIn

MODULES WITH SIMILARITY. "We find that disease pairs with overlapping disease modules display significant molecular similarity, elevated coexpression of their associated genes, and similar symptoms and high comorbidity. At the same time, non-overlapping disease pairs lack any detectable pathobiological relationships." http://science.sciencemag.org/content/347/6224/1257601 View in LinkedIn

NETWORK MODULE. "The network is tightly connected, with the edges typically linking the nodes through multiple genes. Clearly, this network is a module of a much large network that connects most of the virus world." http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-10-158 View in LinkedIn

SHARED GENE FAMILY. "This network also includes at least three distinct groups of viruses, the NCLDV, adenoviruses and an assemblage of bacteriophages." http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-10-158 View in LinkedIn

SHARED JUMPING GENES. "The evolutionary relationship between virophages, polintons and transpovirons is best represented as a network in which the edges correspond to shared genes." http://virologyj.biomedcentral.com/articles/10.1186/1743-422X-10-158 View in LinkedIn

NO DIVIDE. "The discovery of giant viruses infecting unicellular eukaryotes, in particular amoeba, eliminated the distinction between viruses and cellular life forms in terms of size and genomic complexity." https://lnkd.in/eMRxCdg View in LinkedIn

EVOLVING CONCEPTS. "The susceptibility of hereditary mechanisms to biological influences was a matter of intense debate in the late 18th and 19th centuries. With the twin triumphs of Mechanism over Vitalism and Darwinism over Lamarckism in the first half of the 20th century, the Weismann idea of the segregated germ plasm directing the actions of the cell and organism in a hard-wired fashion has been the prevailing view." https://lnkd.in/eFS9cuj View in LinkedIn