Category: Uncategorized

LIMITATIONS. "In complex genomes like humans, the coding genes are about 1.5% of the total genome whereas the abundance of non-coding RNAs are about 98.5%. This means Craig Venter’s household appliance box could focus only on the 1.5% coding sequences." https://lnkd.in/eG_TcWz View in LinkedIn

VENTER'S PERSPECTIVE. "In his view, organisms are mechanistic apparatus-like molecular structures that work as computing machines according the algorithm-based programs encoded in the DNA storage medium. Or, rather, are they coordinated complex entities that share bio-communication properties that may vary according to different context-specific needs?" https://lnkd.in/eG_TcWz View in LinkedIn

VENTER VIEW CHALLENGED. "In his view, the question of Erwin Schrödinger What is life? has been answered. “Life is a DNA software system”, and all living things are reducible to DNA sequences. The DNA-based software creates as well as directs the more visible “hardware” of life, such as proteins and cells." https://lnkd.in/eG_TcWz View in LinkedIn

STRUCTURE AND FUNCTION. "RNA molecules can be divided into secondary structure components, which may have distinct biological functions." https://lnkd.in/erj2nzZ View in LinkedIn

QUASISPECIES CHALLENGED. "Our mainstream picture of RNA virus evolution is determined by the quasispecies concept of Manfred Eigen. It was a very helpful theoretical model within the framework of physical chemistry to paint a picture of viruses with an evolution rate a multitude faster than evolution of cellular organisms." https://lnkd.in/e6fRF6A View in LinkedIn

CONSORTIAL QUASI-SPECIES. "We must look at organisms as phenomena in which complex and dynamic “protein bodies” are regulated by RNA agents that build sequences that have new protein meanings and can act as consortial ribozymatic agents to create networks. The highly stable DNA cellular world is then an omnipresent, comfortable, chemically stable but enzymatically vacant habitat." https://lnkd.in/eUYvi8e View in LinkedIn

PHYSICAL VS BIOLOGICAL SELECTION. "Recent investigations surprisingly indicate that single RNA “stem-loops” operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operates by biological selection." https://lnkd.in/e6fRF6A View in LinkedIn

SYNCHRONIZED SCALING. "The accumulation of junk DNA would indeed scale with accumulating RNA society complexity." https://lnkd.in/eUYvi8e View in LinkedIn

RNA STEM-LOOPS. "If we look at the “body” of these (RNA) social networks, we can see a secondary structure that is shared by all these RNA nucleic acid sequences: it is the stem-loop structure or, in the case of more complex agents such as tRNA or ribosomal subunits, the ligated consortia of such stem loops." https://lnkd.in/eUYvi8e View in LinkedIn

PROTEIN CODING INNOVATION. "RNA agents provide an unlimited potential for new productivity since there is no fundamental limit to be further parasitized by additional agents." https://lnkd.in/eUYvi8e View in LinkedIn