Category: Uncategorized

DUPLICATION CONSEQUENCES. "Responses at the genomic (DNA) level include mutagenic gene silencing or deletional loss, intergenomic transfer of repetitive elements such as transposable elements, differential rates of accumulation of synonymous or nonsynonymous nucleotide substitutions, and various forms of homoeologous (duplicated copies generated by polyploidy) interaction or gene conversion that generate sequences chimeras or duplicated genes (shown as “recombination”)." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn

OBSCURED BY DIVERSITY. "Why was it not classically recognized? The answer to this question lies in the equally surprising spectrum of genomic processes set in motion by polyploidy." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn

DEEP CONSEQUENCES. "This genome multiplicity is an extraordinary realization, with myriad implications for our understanding of genomic architecture, plant gene family structure, and plant function." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn

RANGE OF MULTIPLICATIONS. "Writ large, over the grand sweep of angiosperm history, we now understand that modern angiosperm genomes range in genomic complexity from those that have experienced few genomic multiplication events (e.g., Amborella, Allium, Olea, Theobroma) to others that reflect as many as 128 (Saccharum), 144 (Gossypium), and even 288 (Brassica) genomic multiples." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn

ORIGIN OF PLOIDY. "Polyploids are known to originate within individuals, or following hybridization between closely related populations (auto-polyploidy), or from interspecific hybridization events (allopolyploidy)." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn

BREATHTAKING INSIGHTS. "Nowhere is the pace of progress more apparent than in plant evolutionary genomics, where the application of massively parallel sequencing approaches and advances in computational and bioinformatic capabilities have led to breathtaking insights about the structure, evolution, and function of plant genomes and their various genomic residents." https://lnkd.in/eiPytFX View in LinkedIn

"A GENE'S LINEAGE might have begun by being on a recessive subgenome but subsequently accumulates mutations that lower expression further (e.g., various enhancer deletions, less efficient splice joints, point mutations in the core promoter), including continued accumulation of TE insertions and the mutations caused upon TE excisions. It seems fortunate that we could even measure genome dominance as separate from gene expression." (TE = transposable element). https://lnkd.in/bCmw3Fr View in LinkedIn

SELECTIVE PROCESS. "One intriguing and only partially understood dimension of the genomic diploidization process is that it may be nonrandom with respect to the types of genes retained in duplicate and those returned to single-copy status by mutation." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn

SUBGENOME INEQUALITY. "Once genome dominance is established during the initial inbreeding generations following the polyploidy event itself, genes on one subgenome tend to express less than genes on the other. We predict that this essential inequality begins a cascade of mutational differences based on nothing more profound than “a less expressed gene is easier to mutate” or alter by recombination." https://lnkd.in/bCmw3Fr View in LinkedIn

ANCESTRAL FOOTPRINTS. "This diploidization phenomenon reflects mechanistically diverse processes, operating collectively and over the long haul, ultimately leading to contemporary descendants that behave cytogenetically as normal diploids while harboring in their genomes the vestigial evidence of past polyploidy events." http://www.amjbot.org/content/early/2015/10/09/ajb.1500320 View in LinkedIn