Category: Uncategorized

DESTRUCTION. "Transcripts that lack identity elements are targeted for degradation. In agreement with this model, intronless RNA molecules that have a random sequence are poorly exported from the nucleus and have a very short half-life." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

IDENTITY ELEMENTS. "These mRNA identity features activate coupling reactions, which in turn promote the further processing, nuclear export, and translation of a particular transcript. Likewise, other classes of functional RNAs (e.g., tRNAs and snRNAs) have their own identity elements." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

CODING VS NON-CODING. "On average, protein-coding genes have eight introns, while the majority of annotated ENCODE intergenic transcripts tend not to be spliced." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

COUPLING FUNCTION. "The ultimate goal of these coupling reactions is to sort protein-coding RNAs (i.e. mRNA) from intergenic transcripts." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

COUPLING. "A common theme that has emerged from the study of mRNA synthesis is that various steps in RNA synthesis and processing are biochemically coupled. In other words, cellular machineries that participate in one biochemical activity also promote subsequent steps." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

COUNTER-ARGUMENT. "Although pervasive transcription has been used as an argument against junk DNA, it is in fact entirely in line with the idea that intergenic regions are evolving under little-to-no constraint, especially when one considers that this intergenic transcription is unstable." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

INTERGENIC RNA. "These data indicate that the majority of intergenic RNAs are degraded almost immediately after transcription. Consistent with this idea, the level of intergenic transcripts increase when RNA degradation machinery is inhibited." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

A 100% different perspective... http://qz.com/804022/health-benefits-japanese-forest-bathing/ View in LinkedIn

NUCLEAR HOME. "Strikingly, when one examines the steady state level of polyadenylated RNA, very little maps to intergenic regions. In fact, when one eliminates the ∼9,000 transcript species that are thought to be derived from conserved lncRNA, then most of the annotated noncoding polyadenylated RNAs are present at levels below one copy per cell and are found exclusively in the nucleus." (LncRNAs = long non-coding RNAs). http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn

POLYADENYLATED RNA. "Polyadenylation is an important post-transcriptional modification of prokaryotic, eukaryotic and organellar RNA." https://lnkd.in/eaCHGGt View in LinkedIn