linkedin post 2013-08-12 05:52:36

GENOMICS needs Big Data. Human genome sequence completed 2003, now at 20,000 genes. 3 billion base pairs. But genome sequencing + proteome sequencing gives complexity. Individual genomic and proteomic profiles are key for disease survival. Genes may or may not be turned on. The 20,000 genes produce 200,000 types of RNA coding up to 200,000 proteins. This can result in about a vast number of combinations with hundreds of variant proteins. That is the biomarker challenge. That is Big Data. Proteomics will be computationally bigger than mapping the genome marching sequences to proteins.

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