STARVE THE INVADER. “The aerobic environment and neutral pH of serum ensures that extracellular iron is insoluble and hence difficult to access by invading pathogens. This difficulty is enhanced by the serum protein transferrin, which binds iron with an association constant of approximately 10(36).Taken together, these factors ensure that the amount of free iron available to invading bacteria is vastly less than what is required to replicate and cause disease.”
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