TUMOR “acquisition of specific super-enhancers presumably results from chromosomal translocation, gene amplification, increased transcription factor expression, or somatic mutation of noncoding elements, all of which are known to contribute to tumorigenesis. Interestingly, genomic rearrangements can also contribute to tumorigenesis by simultaneous ectopic transcriptional activation and haploinsufficiency during super-enhancers transitions.”
https://lnkd.in/exFAp7h
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022