linkedin post 2016-06-20 05:13:18

MANY AVENUES. “Given the existence of many DNA polymerases whose fidelity can vary over a 10,000-fold range, and given the multiple and complex transactions that all require DNA synthesis to maintain genome stability, there are probably many more ways to generate mutant cells that thrive despite reduced DNA synthesis fidelity. Thus, the current list of associations between defective DNA synthesis fidelity and cancer is almost certainly incomplete.”

http://www.sciencedirect.com/science/article/pii/S1535610803000278

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