SEPARATION. “Although both autophagy and apoptosis can be activated by 20E, it must be emphasized that, while both 20E commitment and metamorphic peak are required to trigger apoptosis, which produces an increase in apoptosis-related gene expression and activation of the apoptotic pathway, respectively, autophagy might be controlled exclusively by the first 20E peak.” (20E = 20-hydroxyecdysone).
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