SWINGS AND PENDULUMS. “While system-centric studies in specific subfields of biology can be traced back to the 1950s and 1960s, it was not until the mid-1990s that systems biology developed into a major counter-movement that would grow to challenge the reductionist approach.”
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1