LONGEVITY GENE. “The hypopituitary Ames Dwarf Mouse was the seminal example of single-gene regulation of mammalian longevity. The mice homozygous for a hypomorphic df mutation in the Prophet of Pit1, paired-like homeodomain transcription factor (PROP paired-like homeobox 1) (Prop1) gene have deficient development of the anterior portion of the pituitary gland. Consequently, they are deficient in the production of growth hormone, thyroid stimulating hormone, and prolactin.”
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072255
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022