linkedin post 2021-11-20 05:32:58

ORIGIN. “However, the initial spontaneous mutation rate is typically low, as discussed above, so that the fitness cost of producing mutations at even a 100-fold higher rate is small. Furthermore, new hypermutator variants frequently arise because loss-of-function mutations in many genes give rise to this phenotype.”

https://www.nature.com/articles/nrg3564

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