ORIGIN. “However, the initial spontaneous mutation rate is typically low, as discussed above, so that the fitness cost of producing mutations at even a 100-fold higher rate is small. Furthermore, new hypermutator variants frequently arise because loss-of-function mutations in many genes give rise to this phenotype.”
https://www.nature.com/articles/nrg3564
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022