Month: September 2022

MOLECULAR EVOLUTION. "The goal of this review is to bring transcriptional regulation into the mainstream of molecular evolution. We are concerned here with promoters (cis-regulatory sequences that influence transcription) and transcription factors (proteins that interact with these sequences)." A great read. https://lnkd.in/dTi6Znf View in LinkedIn

Asian nations make plastic oceans promise View in LinkedIn

TRANSCRIPTION FACTORS (TF). "It is well known that several transcription factors have DNA binding domains belonging to large paralogous families, although the transcription factors can differ extensively in sequence. Hence, evolution through TFs appears to be a successful strategy for regulation of gene expression." http://www.sciencedirect.com/science/article/pii/S0958166915000208 View in LinkedIn

TRANSCRIPTIONAL REGULATION. "Mutations in Transcriptional Regulation Influence Phenotype. Transcriptional regulation is an integral component of the way genotype is converted into phenotype." https://lnkd.in/dTi6Znf View in LinkedIn

SECTION AT PROMOTOR LEVEL. "Natural Selection Operates on Allelic Variation in Promoters. Promoter polymorphisms at numerous loci in humans have functional consequences that influence diverse aspects of physiology, behavior, anatomy, and life history." https://lnkd.in/dTi6Znf View in LinkedIn

PROMOTORS AND SPECIATION. "Divergence in Promoter Function May Contribute to Reproductive Isolation. Changes in transcriptional regulation may also be important in speciation." https://lnkd.in/dTi6Znf View in LinkedIn

INCREASING COMPLEXITY. "The history of life is punctuated by evolutionary transitions which engender emergence of new levels of biological organization that involves selection acting at increasingly complex ensembles of biological entities." https://lnkd.in/d_h9CX2 View in LinkedIn

STREAMLINING AND OUTSOURCING. Extreme genome reduction in symbiotic bacteria. "These symbionts have numerous features in common, such as extraordinarily fast protein evolution and a high abundance of chaperones. Together, these features point to highly degenerate genomes that retain only the most essential functions, often including a considerable fraction of genes that serve the hosts." https://lnkd.in/dx2k-vt View in LinkedIn

DECEPTIVELY SIMPLE. "Three characteristics contribute to the rapid evolution of these viruses: large populations, short generation times and high mutation rates. Every mutation, which enables its carrier to evade the host’s immune system, will be (positively) selected, passed on to the next generation and distributed more widely. Influenza viruses evolve 1 million times faster than mammals. Five years of virus evolution roughly correspond to the time span, which separates humans and chimpanzees from their last common ancestor." https://lnkd.in/d8xM5QF View in LinkedIn

FRAGMENT FROM NATURE continues from last weekend on the theme of genotype to phenotype conversion, or from DNA to observable traits. We have been immersed in the all-powerful theory of genes and destiny, but the truth is rather different. The radical conclusions we are arriving at today were completely unpredictable only 50 years ago. The phenotype is crafted from a combination of genes and the environment, often across diverse species, finding similar solutions in unrelated creatures. View in LinkedIn